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O-Alkyl S-(Pyridin-2-yl)carbonothiolates: Operationally Simple and Highly Nitrogen-Selective Reagents for Alkoxy Carbonylation of Amino Groups
Synlett ( IF 1.7 ) Pub Date : 2020-03-13 , DOI: 10.1055/s-0039-1690856
Osamu Tamura , Tomoyuki Suzuki , Kosaku Tanaka , Yoshimitsu Hashimoto , Nobuyoshi Morita

Amino groups are selectively protected in good yields by reaction with O-alkyl S-(pyridin-2-yl)carbonothiolates in an appropriate solvent at room temperature in air. Even glucosamine, which contains multiple hydroxyl groups, is selectively N-protected in methanol.

中文翻译:

O-烷基 S-(吡啶-2-基)碳硫醇盐:用于氨基烷氧基羰基化的操作简单且氮选择性高的试剂

通过与 O-烷基 S-(吡啶-2-基)碳硫醇盐在适当的溶剂中在室温下在空气中反应,氨基以良好的产率被选择性地保护。甚至含有多个羟基的葡糖胺也在甲醇中被选择性地 N 保护。
更新日期:2020-03-13
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