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Combination of genetic polymorphisms in TLR influence cytokine profile in HCV patients treated with DAAs in the State of Amazonas
Cytokine ( IF 3.7 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.cyto.2020.155052 Andréa Monteiro Tarragô 1 , Pedro Vieira da Silva Neto 2 , Rajendranath Ramasawmy 3 , Grenda Leite Pereira 2 , Diana Mota Toro 2 , Lilyane de Amorim Xabregas 4 , Allyson Guimaraes Costa 5 , Marilú Barbieri Victória 6 , Flamir da Silva Victória 6 , Adriana Malheiro 1
Cytokine ( IF 3.7 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.cyto.2020.155052 Andréa Monteiro Tarragô 1 , Pedro Vieira da Silva Neto 2 , Rajendranath Ramasawmy 3 , Grenda Leite Pereira 2 , Diana Mota Toro 2 , Lilyane de Amorim Xabregas 4 , Allyson Guimaraes Costa 5 , Marilú Barbieri Victória 6 , Flamir da Silva Victória 6 , Adriana Malheiro 1
Affiliation
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Hepatitis C is a public health problem and affects approximately 3% of the world's population. HCV infections have a wide spectrum of clinical manifestations, and several single nucleotide polymorphisms (SNPs) in the genes of the toll-like receptors are cited to influence the clinical outcomes. A cross-sectional study was conducted in the Amazonas State, Brazil in which SNPs in TLR4 and TLR9 genes were genotyped by PCR-RFLP in 151 HCV chronic liver disease patients and 206 healthy donors. The circulating cytokines IL-6, TNF, IL-10, IL-2, IFN-γ, IL-4 and IL-17A were measured by cytometric bead array (CBA) which revealed that the combined genotypes of TLR9 -1237T/T and -1486C/T seem to influence the cytokine profile under lipopolysaccharide (LPS) stimulation of the Th17 profile, especially among patients with advanced chronic liver disease when treated with DAAs.
中文翻译：
TLR 基因多态性组合影响亚马逊州接受 DAA 治疗的 HCV 患者的细胞因子谱
丙型肝炎是一个公共卫生问题，影响着世界上大约 3% 的人口。 HCV 感染具有广泛的临床表现，Toll 样受体基因中的几个单核苷酸多态性 (SNP) 被认为会影响临床结果。在巴西亚马逊州进行了一项横断面研究，通过 PCR-RFLP 对 151 名 HCV 慢性肝病患者和 206 名健康捐赠者的 TLR4 和 TLR9 基因中的 SNP 进行了基因分型。通过细胞计数珠阵列（CBA）测量循环细胞因子IL-6、TNF、IL-10、IL-2、IFN-γ、IL-4和IL-17A，结果显示TLR9 -1237T/T和TLR9 -1237T/T的组合基因型-1486C/T 似乎会在脂多糖 (LPS) 刺激 Th17 谱的情况下影响细胞因子谱，尤其是在接受 DAA 治疗的晚期慢性肝病患者中。
更新日期：2020-06-01
中文翻译：
TLR 基因多态性组合影响亚马逊州接受 DAA 治疗的 HCV 患者的细胞因子谱
丙型肝炎是一个公共卫生问题，影响着世界上大约 3% 的人口。 HCV 感染具有广泛的临床表现，Toll 样受体基因中的几个单核苷酸多态性 (SNP) 被认为会影响临床结果。在巴西亚马逊州进行了一项横断面研究，通过 PCR-RFLP 对 151 名 HCV 慢性肝病患者和 206 名健康捐赠者的 TLR4 和 TLR9 基因中的 SNP 进行了基因分型。通过细胞计数珠阵列（CBA）测量循环细胞因子IL-6、TNF、IL-10、IL-2、IFN-γ、IL-4和IL-17A，结果显示TLR9 -1237T/T和TLR9 -1237T/T的组合基因型-1486C/T 似乎会在脂多糖 (LPS) 刺激 Th17 谱的情况下影响细胞因子谱，尤其是在接受 DAA 治疗的晚期慢性肝病患者中。
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