The actions of transcriptional coregulators are highly gene-specific, that is, each coregulator is required only for a subset of the genes regulated by a specific transcription factor. These coregulator-specific gene subsets often represent selected physiological responses among multiple pathways targeted by a transcription factor. Regulating the activity of a coregulator via post-translational modifications would thus affect only a subset of the transcription factor's physiological actions. Using the context of transcriptional regulation by steroid hormone receptors, this review focuses on gene-specific actions of coregulators and evidence linking individual coregulators with specific physiological pathways. Such evidence suggests that there is a 'physiological coregulator code', which represents a fertile area for future research with important clinical implications.

中文翻译：

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转录调节剂的基因特异性作用促进生理可塑性：生理调节剂代码的证据。

转录共调节因子的作用是高度基因特异性的，也就是说，每个共调节因子仅是受特定转录因子调控的基因子集所需要的。这些共调节因子特异性基因子集通常代表转录因子靶向的多种途径中的选定生理反应。因此，通过翻译后修饰调节共调节剂的活性将仅影响转录因子的生理作用的一个子集。利用类固醇激素受体的转录调控，本文综述了共调节因子的基因特异性作用，以及将各共调节因子与特定生理途径联系起来的证据。此类证据表明存在“生理调节者代码”，