ER is a highly specialized complex of branched microtubules enclosed in a membrane and communicating with each other, its functions in the cell are important and very diverse: lipid and phospholipid synthesis, calcium storage, hormone synthesis, protein synthesis and maturation, membrane production, toxin neutralization, etc. The high concentration of calcium ions and the oxidizing properties of the contents of the ER cavities contribute to the proper synthesis and folding of proteins designed for secretion or exposure on the surface of the cell membrane. However, disturbance of redox regulation can lead to the accumulation of improperly folded proteins in the ER, disruption of calcium regulation, which can cause ER–stress. This review is devoted to the role of ER–resident selenoproteins in the processes occurring in this organelle of a cell. The main emphasis is placed on the study of protein–protein interactions of selenoproteins with their physiological partners; this will facilitate understanding of their functional purpose in this organelle. Currently, 7 selenoproteins are known that are localized in the ER, but the functions of most of them are not at all clear, for some, physiological partners have been identified. It is known that selenoproteins are oxidoreductases with antioxidant properties, this is extremely important for the normal functioning of ER. Therefore, this review can be very useful for understanding the full picture of the functions of ER–resident selenoproteins obtained on the basis of recent data.

ER是高度专业化的分支微管复合物，封闭在膜中并彼此通讯，它在细胞中的功能非常重要且非常多样：脂质和磷脂合成，钙存储，激素合成，蛋白质合成和成熟，膜产生，毒素高浓度的钙离子和ER腔内容物的氧化特性有助于适当合成和折叠设计用于分泌或暴露在细胞膜表面的蛋白质。但是，氧化还原调节的紊乱会导致内质网中折叠蛋白质的不正确积累，破坏钙质调节，从而引起内质网应激。这篇综述专门讨论了ER驻留硒蛋白在该细胞器中发生的过程中的作用。主要侧重于硒蛋白与其生理伴侣之间的蛋白质-蛋白质相互作用的研究。这将有助于了解他们在该细胞器中的功能目的。目前，已知有7种硒蛋白位于ER中，但其中大多数功能根本不清楚，因为已经鉴定出一些生理伴侣。众所周知，硒蛋白是具有抗氧化特性的氧化还原酶，这对于ER的正常功能极为重要。因此，本综述对于了解基于最新数据获得的ER驻留硒蛋白功能的全貌非常有用。这将有助于了解他们在该细胞器中的功能目的。目前，已知有7种硒蛋白位于ER中，但其中大多数功能根本不清楚，因为已经鉴定出一些生理伴侣。众所周知，硒蛋白是具有抗氧化特性的氧化还原酶，这对于ER的正常功能极为重要。因此，本综述对于了解基于最新数据获得的ER驻留硒蛋白功能的全貌非常有用。这将有助于了解他们在该细胞器中的功能目的。目前，已知有7种硒蛋白位于ER中，但其中大多数功能根本不清楚，因为已经鉴定出一些生理伴侣。众所周知，硒蛋白是具有抗氧化特性的氧化还原酶，这对于ER的正常功能极为重要。因此，本综述对于了解基于最新数据获得的ER驻留硒蛋白功能的全貌非常有用。这对于ER的正常运作极为重要。因此，本综述对于了解基于最新数据获得的ER驻留硒蛋白功能的全貌非常有用。这对于ER的正常运转极为重要。因此，本综述对于了解基于最新数据获得的ER驻留硒蛋白功能的全貌非常有用。