Spinal cord injury (SCI) is a common disease and a major cause of paralysis, carrying much burden around the world. Despite the progress made with growth factors therapy, the response rate of acute SCI treatment still remains unsatisfactory, due largely to complex and severe inflammatory reactions. Herein, we prepare a MFG-E8-loaded copolymer system-based anti-inflammation therapy for SCI treatment. It is shown that the MFG-E8-loaded copolymer system can decrease pro-inflammatory cytokine expression and neuron death. In a rat model of crush-caused SCI, the copolymer system shows significant therapeutic efficacy by ameliorating inflammation, decreasing fibrotic scar, promoting myelin regeneration and suppressing overall SCI severity.

中文翻译：

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一种可注射的重组人乳脂肪球-表皮生长因子 8 共聚物系统通过减少 NF-κB 通路的炎症和神经元细胞死亡来治疗脊髓损伤

脊髓损伤（SCI）是一种常见疾病，也是导致瘫痪的主要原因，在世界范围内承载着沉重的负担。尽管生长因子治疗取得了进展，但主要由于复杂和严重的炎症反应，急性 SCI 治疗的反应率仍然不令人满意。在此，我们制备了一种基于 MFG-E8 共聚物系统的抗炎疗法，用于 SCI 治疗。结果表明，装载 MFG-E8 的共聚物系统可以减少促炎细胞因子的表达和神经元死亡。在挤压引起的 SCI 大鼠模型中，共聚物系统通过改善炎症、减少纤维化疤痕、促进髓鞘再生和抑制整体 SCI 严重程度显示出显着的治疗效果。