Food allergy and allergen management are important global public health issues. In 2011, the first iteration of our allergen threshold database (ATDB) was established based on individual NOAELs and LOAELs from oral food challenge in roughly 1750 allergic individuals. Population minimal eliciting dose (EDp) distributions based on this dataset were published for 11 allergenic foods in 2014. Systematic data collection has continued (2011-2018) and the dataset now contains over 3400 data points. The current study provides new and updated EDp values for 14 allergenic foods and incorporates a newly developed Stacked Model Averaging statistical method for interval-censored data. ED01 and ED05 values, the doses at which 1%, and respectively 5%, of the respective allergic population would be predicted to experience any objective allergic reaction were determined. The 14 allergenic foods were cashew, celery, egg, fish, hazelnut, lupine, milk, mustard, peanut, sesame, shrimp (for crustacean shellfish), soy, walnut, and wheat. Updated ED01 estimates ranged between 0.03 mg for walnut protein and 26.2 mg for shrimp protein. ED05 estimates ranged between 0.4 mg for mustard protein and 280 mg for shrimp protein. The ED01 and ED05 values presented here are valuable in the risk assessment and subsequent risk management of allergenic foods.

中文翻译：

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更新了人口最小诱发剂量分布，以用于14种优先食物过敏原的风险评估。

食物过敏和过敏原管理是重要的全球公共卫生问题。2011年，我们基于大约1750名过敏者口服食品挑战中的个体NOAEL和LOAEL建立了我们的过敏原阈值数据库（ATDB）的第一版。2014年，根据该数据集发布了11种过敏性食品的种群最小诱发剂量（EDp）分布。系统数据收集仍在继续（2011-2018），数据集现在包含3400多个数据点。当前的研究为14种变应性食品提供了新的和更新的EDp值，并结合了新开发的间隔时间间隔数据的堆积模型平均统计方法。ED01和ED05值，分别为1％和5％时的剂量 据预测，每个过敏人群中有1-2％会经历任何客观的过敏反应。这14种变应原性食物包括腰果，芹菜，鸡蛋，鱼，榛子，羽扇豆，牛奶，芥末，花生，芝麻，虾（甲壳类贝类），大豆，核桃和小麦。ED01的最新估算值介于核桃蛋白0.03毫克和虾蛋白26.2毫克之间。ED05估计的芥菜蛋白含量为0.4 mg，虾蛋白的含量为280 mg。此处显示的ED01和ED05值在过敏性食品的风险评估和后续风险管理中很有价值。虾蛋白2毫克。ED05估计的芥菜蛋白含量为0.4 mg，虾蛋白的含量为280 mg。此处显示的ED01和ED05值在过敏性食品的风险评估和后续风险管理中非常有价值。虾蛋白2毫克。ED05估计的芥菜蛋白含量为0.4 mg，虾蛋白的含量为280 mg。此处显示的ED01和ED05值在过敏性食品的风险评估和后续风险管理中很有价值。