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Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo.
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2020-03-13 , DOI: 10.1016/j.bioorg.2020.103758 Lijun An 1 , Jun Ma 1 , Xueyuan Yang 1 , Yue Liang 1 , Huimei Wang 1 , Muhetaer Tuerhong 2 , Namrita Lall 3 , Munira Abudukeremu 2 , Yi Zhang 4 , Dongho Lee 5 , Jing Xu 6 , Xiaohui Wu 7 , Yuanqiang Guo 1
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2020-03-13 , DOI: 10.1016/j.bioorg.2020.103758 Lijun An 1 , Jun Ma 1 , Xueyuan Yang 1 , Yue Liang 1 , Huimei Wang 1 , Muhetaer Tuerhong 2 , Namrita Lall 3 , Munira Abudukeremu 2 , Yi Zhang 4 , Dongho Lee 5 , Jing Xu 6 , Xiaohui Wu 7 , Yuanqiang Guo 1
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Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.
中文翻译：
Caseahomopene A，一种来自卡氏菌的环膨胀的同型三萜类化合物，在体外和体内均具有抗炎活性。
从卡氏菌属的叶子中分离出一种稀有的具有环扩展的同三萜骨架的天然产物酪胺酮A（1）。通过光谱数据和X射线晶体学分析确定包括绝对构型的结构。使用LPS刺激的细胞和斑马鱼模型，化合物1在体外和体内均显示出抗炎作用。作为潜在的消炎药，还研究了1的消炎机理。
更新日期：2020-03-16
中文翻译：
Caseahomopene A，一种来自卡氏菌的环膨胀的同型三萜类化合物，在体外和体内均具有抗炎活性。
从卡氏菌属的叶子中分离出一种稀有的具有环扩展的同三萜骨架的天然产物酪胺酮A（1）。通过光谱数据和X射线晶体学分析确定包括绝对构型的结构。使用LPS刺激的细胞和斑马鱼模型，化合物1在体外和体内均显示出抗炎作用。作为潜在的消炎药，还研究了1的消炎机理。
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