The impact of extract composition on the neuroprotective activities of Ecklonia radiata was investigated in multiple neuroprotective assays in vitro. A total of six fractions (crude extract (CE), phlorotannin (PT), polysaccharide (PS), free sugar (FS), low molecular weight (LM), and high molecular weight (HM)) prepared from E. radiata were used to determine their effects against Aβ1-42 and oxidative stress in neuronal cell line PC-12. Only three fractions (CE, PS, and HM) demonstrated cytotoxicity in at least the highest concentration (100 μg/mL) tested in PC-12 cells. All fractions inhibited apoptosis induced by Aβ1-42 and enhanced neurite outgrowth activity. With the exception of HM, other fractions inhibited the aggregation of Aβ1-42 and demonstrated antioxidant activity against the toxicity induced by hydrogen peroxide. This study highlights the potential of using brown seaweed E. radiata components for improving neuroprotective activities. Such extracts could be potentially used as functional food or dietary supplements to support neurological function.

在体外多种神经保护实验中研究了提取物组成对辐射夜蛾神经保护活性的影响。从制备的共六个级分（粗提取物（CE），phlorotannin（PT），多糖（PS），无糖（FS），低分子量（LM），和高分子量（HM））E.辐射用来确定它们对神经元细胞系PC-12中Aβ1-42和氧化应激的作用。在PC-12细胞中测试的至少最高浓度（100μg/ mL）中，只有三部分（CE，PS和HM）显示出细胞毒性。所有级分均抑制由Aβ1-42诱导的凋亡，并增强神经突向外生长活性。除HM外，其他部分均抑制Aβ1-42的聚集并显示出抗过氧化氢诱导的毒性的抗氧化活性。这项研究强调了使用褐紫菜放射线虫成分改善神经保护活性的潜力。此类提取物有可能被用作功能性食品或膳食补充剂，以支持神经功能。