Excessive exposure to ultraviolet B (UVB) radiation causes skin aging (a process known as photoaging). This study examined whether subchronic (14-week) oral administration of a novel hydrolyzed chicken sternal cartilage extract—comprising naturally-occurring primarily hydrolyzed type II collagen peptides, chondroitin sulfate and hyaluronic acid, extracted from a single source—could reduce signs associated with photoaging in hairless mice. Administration of the extract to UVB-irradiated mice led to significant increases in skin elasticity and hyaluronic acid content, compared with UVB-irradiated controls. Matrix metalloproteinase expression, transepidermal water loss, dermal inflammatory cells and wrinkles were all significantly reduced by administration of hydrolyzed chicken sternal cartilage extract. This study is the first to demonstrate that oral administration of this novel extract, containing a unique single-source complex of primarily hydrolyzed type II collagen (rather than the more widely studied type I form), chondroitin sulfate and hyaluronic acid, reduces UVB-induced photoaging in hairless mice.

过度暴露于紫外线B（UVB）辐射会导致皮肤老化（此过程称为光老化）。这项研究检查了慢性（14周）口服新型水解鸡胸骨软骨提取物（其包含从单一来源提取的天然存在的主要水解的II型胶原蛋白肽，硫酸软骨素和透明质酸）是否可以减少与光老化相关的症状在无毛小鼠中。与UVB辐照的对照组相比，将提取物给予UVB辐照的小鼠会导致皮肤弹性和透明质酸含量的显着增加。水解鸡胸骨软骨提取物可显着降低基质金属蛋白酶的表达，表皮水分流失，皮肤炎性细胞和皱纹。