We offer a concept for the simultaneous determination of QuEChERS amenable and highly polar pesticides using two-dimensional liquid chromatography high resolution mass spectrometry with electrospray ionization (ESI) and polarity switching. First results proved feasibility to determine glyphosate, AMPA, ethephon, glufosinate, MPPA, fosetyl-Al, N-acetyl-glufosinate, N-acetyl-glyphosate and N-acetyl-AMPA including fragments, next to 325 QuEChERS amenable pesticides. We plan to investigate an efficient extraction procedure by either diluting with water or acetonitrile extraction in mini scale without the need for additional clean-up steps. After completion of all experiments, the method will be validated and expanded for further pesticides and organic contaminants. Therefore, we present a concept for a Two-dimensional HILIC Reversed phase Easily Extracted Pesticides and Polar Pesticides (THREEP or 3P(+)) multi-residue method.

中文翻译：

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二维亲水相互作用和反相液相色谱法很容易提取农药和极性农药的多残留方法-一个概念。

我们提供使用二维液相色谱高分辨质谱联用电喷雾电离（ESI）和极性切换同时测定QuEChERS适宜和高极性农药的概念。初步结果证明了测定除草甘膦，AMPA，乙烯利，草铵膦，MPPA，乙磷酰胺，N-乙酰基草铵膦，N-乙酰基草甘膦和N-乙酰基-AMPA（包括片段）以及325种QuEChERS适宜农药的可行性。我们计划通过用水稀释或以小规模乙腈萃取来研究一种有效的萃取程序，而无需额外的清理步骤。完成所有实验后，将对该方法进行验证并扩展到其他农药和有机污染物。因此，