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Structural mediation of human brain activity revealed by white-matter interpolation of fMRI
NeuroImage ( IF 4.7 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.neuroimage.2020.116718
Anjali Tarun 1 , Hamid Behjat 2 , Thomas Bolton 1 , David Abramian 3 , Dimitri Van De Ville 1
Affiliation  

Understanding how the anatomy of the human brain constrains and influences the formation of large-scale functional networks remains a fundamental question in neuroscience. Here, given measured brain activity in gray matter, we interpolate these functional signals into the white matter on a structurally-informed high-resolution voxel-level brain grid. The interpolated volumes reflect the underlying anatomical information, revealing white matter structures that mediate the interaction between temporally coherent gray matter regions. Functional connectivity analyses of the interpolated volumes reveal an enriched picture of the default mode network (DMN) and its subcomponents, including the different white matter bundles that are implicated in their formation, thus extending currently known spatial patterns that are limited within the gray matter only. These subcomponents have distinct structure-function patterns, each of which are differentially observed during tasks, demonstrating plausible structural mechanisms for functional switching between task-positive and -negative components. This work opens new avenues for the integration of brain structure and function, and demonstrates the collective mediation of white matter pathways across short and long-distance functional connections.

中文翻译:

fMRI 白质插值揭示的人类大脑活动的结构中介

了解人类大脑的解剖结构如何限制和影响大规模功能网络的形成仍然是神经科学中的一个基本问题。在这里,考虑到灰质中测量的大脑活动,我们将这些功能信号插入到具有结构信息的高分辨率体素级大脑网格上的白质中。插值体积反映了潜在的解剖信息,揭示了介导时间连贯灰质区域之间相互作用的白质结构。内插体积的功能连接分析揭示了默认模式网络 (DMN) 及其子组件的丰富图片,包括涉及其形成的不同白质束,从而扩展了目前已知的仅限于灰质内的空间模式. 这些子组件具有不同的结构 - 功能模式,在任务期间观察到的每一种模式都不同,展示了任务积极和消极组件之间功能切换的合理结构机制。这项工作为整合大脑结构和功能开辟了新途径,并证明了白质通路在短距离和长距离功能连接中的集体调节。
更新日期:2020-06-01
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