Breast cancer is the frequently diagnosed cancer among women and it is the most lethal malignancy in women globally. With one million cases every year, breast cancer is the fast-growing cancer type that has a high prevalence rate in young women. The limitations and undesirable side effects of conventional therapies like chemotherapy and radiotherapy on malignant tumors necessitate the development of alternative therapeutic approaches. Gene therapy has emerged as a promising approach to cure a variety of malignant cancer types which involves the delivery of functional gene directly into the target tumor tissue. Efficient gene therapy approach relies on the effective delivery of therapeutic genes to the desired cell type. In this regard, biological and non-biological gene delivery vectors are used to protect the naked foreign DNA to mediate effective tissue entry of the desired gene of interest. In this review, the use of bacterial and viral vectors for breast cancer gene therapy was summarized.

中文翻译：

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细菌和病毒载体作为乳腺癌治疗的疫苗输送载体。

乳腺癌是女性中经常被诊断出的癌症，并且是全球女性中最致命的恶性肿瘤。乳腺癌每年有一百万例，是快速增长的癌症类型，在年轻女性中患病率很高。传统疗法（如化学疗法和放射疗法）对恶性肿瘤的局限性和不良副作用使得必须开发其他治疗方法。基因治疗已经成为治疗各种恶性癌症的一种有前途的方法，涉及将功能基因直接递送到靶肿瘤组织中。高效的基因治疗方法依赖于将治疗基因有效递送至所需细胞类型。在这方面，生物和非生物基因递送载体用于保护裸露的外源DNA，以介导所需目的基因的有效组织进入。在这篇综述中，总结了细菌和病毒载体在乳腺癌基因治疗中的应用。