Objective measurement of sleep in mild cognitive impairment: A systematic review and meta-analysis.,Sleep Medicine Reviews

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Objective measurement of sleep in mild cognitive impairment: A systematic review and meta-analysis.
Sleep Medicine Reviews ( IF 10.5 ) Pub Date : 2020-03-13 , DOI: 10.1016/j.smrv.2020.101308
Angela L D'Rozario ₁ , Julia L Chapman ₂ , Craig L Phillips ₃ , Jake R Palmer ₄ , Camilla M Hoyos ₁ , Loren Mowszowski ₅ , Shantel L Duffy ₆ , Nathaniel S Marshall ₃ , Ruth Benca ₇ , Bryce Mander ₇ , Ronald R Grunstein ₈ , Sharon L Naismith ₅

Affiliation

School of Psychology, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia; Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; Woolcock Institute of Medical Research, University of Sydney, Glebe, New South Wales, Australia.
Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia; Woolcock Institute of Medical Research, University of Sydney, Glebe, New South Wales, Australia.
Woolcock Institute of Medical Research, University of Sydney, Glebe, New South Wales, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia; School of Psychology, Macquarie University, Sydney, New South Wales, Australia.
School of Psychology, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia; Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia; Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; Woolcock Institute of Medical Research, University of Sydney, Glebe, New South Wales, Australia; Discipline of Exercise and Sport Science, Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, Australia.
Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
Woolcock Institute of Medical Research, University of Sydney, Glebe, New South Wales, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Older adults with mild cognitive impairment (MCI) are at-risk of developing dementia, particularly Alzheimer's disease. While some research suggests that alterations in sleep architecture may mediate cognitive decline, the nature and magnitude of changes to sleep macro- (sleep stages) and micro-architecture (electroencephalography (EEG) oscillations) in MCI is not yet clear. This study aimed to systematically review and meta-analyse case–control studies objectively measuring sleep in MCI. A systematic search was conducted using PubMed, Scopus, Web of Science, Embase and Psycinfo databases and after review, a total of 10 studies met inclusion criteria. Of these, all reported sleep macro-architecture and four reported micro-architecture outcomes. A combined total of 430 participants (209 with and 221 without MCI) underwent objective sleep assessments in the included full text articles. Findings show that compared to healthy controls, those with MCI have pronounced changes in sleep macro-architecture with greater wake after sleep onset, reduced total sleep time, lower sleep efficiency, longer sleep onset latency, longer rapid eye movement sleep (REM) latency, reduced REM sleep, greater N1 sleep, and worse severity of hypoxemia. Pooling of sleep micro-architecture EEG measures was not possible due to limited studies, however reduced spindles in non-REM sleep and greater EEG slowing in REM sleep were reported.

中文翻译：

轻度认知障碍中睡眠的客观测量：系统评价和荟萃分析。

患有轻度认知障碍（MCI）的老年人患痴呆症的风险较高，尤其是阿尔茨海默氏病。尽管一些研究表明，睡眠结构的改变可能会介导认知功能下降，但MCI中睡眠宏（睡眠阶段）和微结构（脑电图（EEG）振荡）变化的性质和幅度尚不清楚。这项研究旨在系统地回顾和荟萃分析病例对照研究，从而客观地测量MCI中的睡眠。使用PubMed，Scopus，Web of Science，Embase和Psycinfo数据库进行了系统的搜索，经过审查，总共有10项符合纳入标准的研究。其中，所有报告的睡眠宏架构和四个报告的微架构结果。包括在全文中的总共430名参与者（209名有MCI的参与者和221名无MCI的参与者）进行了客观睡眠评估。研究结果表明，与健康对照组相比，患有MCI的患者的睡眠宏结构发生了明显变化，入睡后觉醒时间更长，总睡眠时间减少，睡眠效率降低，睡眠开始潜伏期更长，快速眼动睡眠（REM）潜伏期更长， REM睡眠减少，N1睡眠增加，低氧血症的严重程度恶化。由于研究有限，无法合并睡眠微体系结构EEG措施，但是据报道，非REM睡眠中纺锤体减少，而REM睡眠中EEG减慢幅度更大。患有MCI的患者的睡眠宏结构发生了显着变化，包括睡眠开始后的唤醒时间更长，总睡眠时间减少，睡眠效率降低，睡眠开始潜伏期延长，快速眼动睡眠（REM）潜伏期延长，REM睡眠减少，N1睡眠增加，低氧血症的严重程度更高。由于研究有限，无法合并睡眠微体系EEG量度，但据报道非REM睡眠中梭形减少，而REM睡眠中EEG减慢更大。患有MCI的患者的睡眠宏结构发生了显着变化，包括睡眠开始后的唤醒时间更长，总睡眠时间减少，睡眠效率降低，睡眠开始潜伏期延长，快速眼动睡眠（REM）潜伏期延长，REM睡眠减少，N1睡眠增加，低氧血症的严重程度更高。由于研究有限，无法合并睡眠微体系结构EEG措施，但是据报道，非REM睡眠中纺锤体减少，而REM睡眠中EEG减慢幅度更大。

更新日期：2020-03-13

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