Recent studies showed that dyslipidemia could be a critical factor in the progression of cardiovascular disease in systemic lupus erythematosus (SLE). The aim of the present study was to describe the relationship between serum lipid profile and SLE disease activity in young female adults with SLE. Seventy-one female subjects diagnosed with SLE aged 20~30 years were enrolled. Serum lipid profile including TC, TG, HDL-C, LDL-C, VLDL-C, Apo A, Apo B, and Apo E were evaluated between control and young female SLE patients. Univariate correlation analyses were performed to explore the correlation between serum lipid levels and SLE disease activity. Our results showed that TG and VLDL-C levels were significantly increased in young female SLE as compared to control, with TC, HDL-C, LDL-C, Apo A, and Apo B significantly reduced. Meanwhile, univariate correlation analyses showed negative correlations between SLE disease activity index and HDL-C, LDL-C, Apo A, and Apo B; with positive correlations between SLE disease activity index and TG and VLDL-C. Serum lipid profile was significantly dysregulated in young female SLE patients. Moreover, SLE disease activity was correlated to the serum lipid levels, supporting the notion that the young patients with SLE might also have a higher risk of cardiovascular disease.

中文翻译：

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诊断为系统性红斑狼疮的年轻女性成年人血清脂质分布失调及其与疾病活动的相关性：一项横断面研究

最近的研究表明，血脂异常可能是系统性红斑狼疮（SLE）心血管疾病进展的关键因素。本研究的目的是描述年轻女性SLE患者的血脂水平与SLE疾病活动之间的关系。入选了21位年龄在20至30岁之间的SLE女性受试者。在对照和年轻女性SLE患者之间评估了包括TC，TG，HDL-C，LDL-C，VLDL-C，Apo A，Apo B和Apo E的血清脂质谱。进行单因素相关分析以探讨血清脂质水平与SLE疾病活动性之间的相关性。我们的结果表明，与对照相比，年轻女性SLE中TG和VLDL-C水平显着增加，而TC，HDL-C，LDL-C，Apo A和Apo B显着降低。与此同时，单因素相关分析表明，SLE疾病活动指数与HDL-C，LDL-C，Apo A和Apo B呈负相关。与SLE疾病活动指数与TG和VLDL-C呈正相关。年轻女性SLE患者的血脂水平明显失调。此外，SLE疾病活动性与血脂水平相关，这支持年轻SLE患者可能也有较高心血管疾病风险的观点。