Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms.,ACS Chemical Neuroscience

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Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-03-13 , DOI: 10.1021/acschemneuro.0c00122
Abdul Mannan Baig ₁ , Areeba Khaleeq ₁ , Usman Ali ₂ , Hira Syeda ₃

Affiliation

The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. As we are in the midst of an ongoing pandemic of COVID-19, scientists are struggling to understand how it resembles and differs from the severe acute respiratory syndrome coronavirus (SARS-CoV) at the genomic and transcriptomic level. In a short time following the outbreak, it has been shown that, similar to SARS-CoV, COVID-19 virus exploits the angiotensin-converting enzyme 2 (ACE2) receptor to gain entry inside the cells. This finding raises the curiosity of investigating the expression of ACE2 in neurological tissue and determining the possible contribution of neurological tissue damage to the morbidity and mortality caused by COIVD-19. Here, we investigate the density of the expression levels of ACE2 in the CNS, the host-virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak. Also, we debate the need for a model for staging COVID-19 based on neurological tissue involvement.

中文翻译：

COVID-19 病毒针对中枢神经系统的证据：组织分布、宿主-病毒相互作用和拟议的神经机制。

最近爆发的 2019 年冠状病毒传染病 (COVID-19) 引起了全世界的担忧，并引发了人们对其在全球范围内传播和感染人类的可能性的极大恐慌。由于我们正处于 COVID-19 的持续大流行之中，科学家们正在努力了解它在基因组和转录组水平上与严重急性呼吸综合征冠状病毒 (SARS-CoV) 的相似之处和不同之处。疫情爆发后不久，研究表明，与 SARS-CoV 类似，COVID-19 病毒利用血管紧张素转换酶 2 (ACE2) 受体进入细胞内部。这一发现引发了人们对研究神经组织中 ACE2 的表达以及确定神经组织损伤对 COIVD-19 引起的发病率和死亡率的可能贡献的好奇心。在这里，我们研究了中枢神经系统中 ACE2 表达水平的密度、宿主与病毒的相互作用，并将其与最近由 COVID-19 爆发引起的病例中发现的发病机制和并发症联系起来。此外，我们还讨论了是否需要一种基于神经组织受累情况来对 COVID-19 进行分期的模型。

更新日期：2020-03-16

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