Computed Tomography Imaging-Guided Tandem Catalysis-Enhanced Photodynamic Therapy with Gold Nanoparticle Functional Covalent Organic Polymers,ACS Applied Bio Materials

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Computed Tomography Imaging-Guided Tandem Catalysis-Enhanced Photodynamic Therapy with Gold Nanoparticle Functional Covalent Organic Polymers
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-03-12 , DOI: 10.1021/acsabm.0c00244
Hua-Qing Yin ₁ , Pei-Pei Cao ₂ , Xin-Yao Wang ₁ , Yu-Hao Li ₂ , Xue-Bo Yin ₁

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Tandem catalysis from hydrogen peroxide (H₂O₂) to oxygen (O₂) and then to singlet oxygen (¹O₂) is a convenient way to overcome the hypoxic environment of the tumor for efficient cancer therapy. In this work, meso-tetrakis(4-carboxyl)-21H,23H-porphine (TCPP) and β-cyclodextrin (β-CD) functional gold nanoparticles (CD-AuNPs) are integrated together with a brushy covalent organic polymer (COP-8) to form COP@Au@TCPP nanocomposites. The brushy red emissive COP-8 was prepared with 9,9-dioctyl-2,7-diaminofluorene and 2,4,6-triformylphloroglucinol through a simple Schiff base reaction and acts as a sensor to monitor the material transfer and location in tumor cells. The n-octyl groups on the surface of COP-8 act as hooks to load CD-AuNPs via hydrophobic interaction, while the β-CD improves the biocompatibility of the whole COP@Au@TCPP. The COP@Au@TCPP nanocomposites aggregate efficiently in the tumor site through enhanced permeability and retention effect. The CD-AuNPs act as catalyzers to decompose H₂O₂ into O₂ in tumor cells. Then, TCPPs on COP@Au@TCPP sensitize O₂ to form ¹O₂ under 655 nm radiation for efficient photodynamic therapy (PDT). In combination with the X-ray computed tomography (CT) imaging capacity of CD-AuNPs, the CT-imaging-guided PDT system was successfully prepared. The imaging information, in turn, shows the tandem catalysis PDT efficiency of the COP@Au@TCPP. This work paves the way for the preparation of an imaging-guided therapy system with COP as a matrix to ingrate various biocompatibility components.

中文翻译：

计算机断层扫描成像引导的串联催化增强的金纳米粒子功能共价有机聚合物光动力疗法

从过氧化氢（H ₂ O ₂）到氧气（O ₂）再到单线态氧（¹ O ₂）的串联催化是克服肿瘤缺氧环境进行有效癌症治疗的便捷方法。在这项工作中，meso-tetrakis(4-carboxyl)-21 H ,23 H-卟啉 (TCPP) 和 β-环糊精 (β-CD) 功能性金纳米粒子 (CD-AuNPs) 与刷状共价有机聚合物 (COP-8) 结合在一起形成 COP@Au@TCPP 纳米复合材料。使用 9,9-二辛基-2,7-二氨基芴和 2,4,6-三甲酰基间苯三酚通过简单的席夫碱反应制备刷状红色发射 COP-8，并作为传感器监测肿瘤细胞中的物质转移和定位. COP-8表面的正辛基作为钩子通过疏水相互作用负载CD-AuNPs，而β-CD提高了整个COP@Au@TCPP的生物相容性。COP@Au@TCPP 纳米复合材料通过增强的渗透性和滞留效应有效地聚集在肿瘤部位。CD-AuNPs 作为催化剂分解 H ₂ O ₂转化为肿瘤细胞中的 O ₂。然后，COP@Au@TCPP 上的 TCPP 在 655 nm 辐射下使 O ₂敏感形成¹ O ₂，用于有效的光动力治疗（PDT）。结合CD-AuNPs的X射线计算机断层扫描（CT）成像能力，成功制备了CT成像引导的PDT系统。反过来，成像信息显示了 COP@Au@TCPP 的串联催化 PDT 效率。这项工作为制备以 COP 为基质的成像引导治疗系统以整合各种生物相容性组件铺平了道路。

更新日期：2020-03-12

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