METHODS Using data from a provincial newborn screen and healthcare database for 12,587 children born in 2004, maternal distress was defined as: prenatal, and self-limiting, recurrent or late-onset postpartum. Atopic dermatitis (AD) and asthma at ages 5 and 7 were diagnosed from hospitalization, physician visit or prescription records. Associations between maternal distress, and childhood asthma and AD were determined with multiple logistic regression. RESULTS After adjusting for risk factors, a significant association between maternal prenatal (OR 1.27, 95%CI 1.11-1.46), recurrent postpartum (OR 1.28, 95%CI 1.11-1.48), and late-onset postpartum distress (OR 1.19, 95%CI 1.06-1.34) was found with AD at 5 years. Asthma at 7 was also associated with maternal prenatal distress (OR 1.57, 95%CI 1.29-1.91) and late-onset postnatal distress (OR 1.22, 95%CI 1.01-1.46). Self-limiting postnatal distress was not found to be a risk factor for either atopic condition. Associations with AD or asthma were of a similar magnitude in boy and girls, except that recurrent postnatal distress increased risk for asthma in boys only. CONCLUSION This population-based study provides evidence for sex-specific associations between maternal pre- and postnatal distress, and the development of AD and asthma. Our findings support recommendations for greater psychosocial support of mothers during pregnancy and early childhood to prevent childhood atopic disease.

中文翻译：

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孕期母亲痛苦和儿童早期复发预示儿童特应性皮炎和哮喘

方法 使用省级新生儿筛查和医疗保健数据库中 2004 年出生的 12,587 名儿童的数据，将孕产妇窘迫定义为：产前、自限性、复发性或迟发性产后。5 岁和 7 岁的特应性皮炎 (AD) 和哮喘是通过住院、医生就诊或处方记录诊断出来的。产妇痛苦与儿童哮喘和 AD 之间的关联是通过多元逻辑回归确定的。结果 调整风险因素后，母亲产前 (OR 1.27, 95%CI 1.11-1.46)、产后复发 (OR 1.28, 95%CI 1.11-1.48) 和迟发性产后窘迫 (OR 1.19, 95 %CI 1.06-1.34) 在 5 年时发现患有 AD。7 岁时的哮喘还与母亲产前不适（OR 1.57，95%CI 1.29-1.91）和迟发性产后不适（OR 1.22，95% CI 1.01-1.46)。未发现自限性产后窘迫是任何一种特应性疾病的危险因素。男孩和女孩与 AD 或哮喘的关联程度相似，只是反复出现的产后不适仅增加男孩患哮喘的风险。结论这项基于人群的研究为产前和产后痛苦与 AD 和哮喘的发展之间的性别特异性关联提供了证据。我们的研究结果支持在怀孕和幼儿期为母亲提供更多社会心理支持以预防儿童特应性疾病的建议。除了反复出现的产后痛苦只会增加男孩患哮喘的风险。结论这项基于人群的研究为产前和产后痛苦与 AD 和哮喘的发展之间的性别特异性关联提供了证据。我们的研究结果支持在怀孕和幼儿期为母亲提供更多社会心理支持以预防儿童特应性疾病的建议。除了反复出现的产后痛苦只会增加男孩患哮喘的风险。结论这项基于人群的研究为产前和产后痛苦与 AD 和哮喘的发展之间的性别特异性关联提供了证据。我们的研究结果支持在怀孕和幼儿期为母亲提供更多社会心理支持以预防儿童特应性疾病的建议。