In the search for soft and smart materials for nanomedicine, which is a present challenge, supramolecular nanohydrogels built on self-assembling low-molecular-weight building blocks attract interest for their structural, mechanical and functional properties. Herein, we describe a supramolecular nanohydrogel formed by a biofriendly micellar self-assembling choline-calix[4]arene derivative in the presence of curcumin, a natural and multitarget pharmacologically relevant drug. Morphology and mechanical properties of the nanohydrogel were investigated, and theoretical simulation performed to model the nanohydrogel structure. The self-healing and injectable nanohydrogel easily formed in PBS medium at physiologic pH, without using additives and organic solvents. The micellar nanohydrogel protected curcumin from rapid chemical and photochemical degradation, and slowly dissolved in curcumin-loaded micelles sustaining the drug release in a low rate. The nanohydrogel which combines the mechanical properties of a hydrogel and the benefits of a nanoscale micelle in drug delivery, appears a promising novel material for drug delivery.

在寻找软和智能的纳米医学材料时，这是当前的挑战，基于自组装低分子量结构单元的超分子纳米水凝胶因其结构，机械和功能特性而引起人们的关注。在本文中，我们描述了由姜黄素（一种天然的和多目标药理相关的药物）存在的生物友好的胶束自组装胆碱杯[4]芳烃衍生物形成的超分子纳米水凝胶。研究了纳米水凝胶的形貌和力学性能，并进行了理论模拟以模拟纳米水凝胶的结构。无需使用添加剂和有机溶剂，即可在生理pH值的PBS介质中轻松形成可自我修复的可注射纳米水凝胶。胶束纳米水凝胶可保护姜黄素免受化学和光化学作用的快速降解，并缓慢溶解于负载姜黄素的胶束中，从而维持药物以低速率释放。结合了水凝胶的机械性能和纳米级胶束在药物输送中的优势的纳米水凝胶，似乎是一种有前途的新型药物输送材料。