This study provides a new therapeutic response to postoperative joint and bone infections. Alone or in combination with antibiotics, phage therapy has many advantages, including accurate targeting of pathogenic bacteria. In addition, a decrease in harmful side effects can improve the healing process. Integrating the bacteriophage directly into the graft product will improve the antibacterial spread over the site of the surgery. The phage cocktail-filled ceramics are an innovative device for localized and curative phage therapy (in prosthetic replacement surgery, for example) in bone and joint surgery. Calcium phosphate-based ceramics were synthesized and shaped by stereolithography (3D) before loading by a phage cocktail to lyse a heterospecific bacterial population. In addition, the device makes possible the protection of osteoblastic cells against Staphylococcus aureus infection during their colonization on the ceramic material and prevents the formation of biofilm on the surface of biomaterials.

这项研究为术后关节和骨感染提供了一种新的治疗方法。单独或与抗生素结合使用，噬菌体疗法具有许多优势，包括准确靶向致病菌。此外，减少有害副作用可以改善愈合过程。将噬菌体直接整合到移植产品中将改善抗菌素在手术部位的扩散。噬菌体混合物填充的陶瓷是一种创新的设备，用于骨骼和关节手术中的局部和治愈性噬菌体治疗（例如，在人工修复手术中）。合成磷酸钙基陶瓷并通过立体平版印刷术（3D）成型，然后通过噬菌体混合物加载以裂解异种细菌种群。此外，金黄色葡萄球菌在定植于陶瓷材料期间会受到感染，并防止在生物材料表面形成生物膜。