The control of massive bleeding and its related wound infection is the main challenge for both military and civilian trauma centres. In this study, a cationic superabsorbent hydrogel coordinated by mesoporous silica (CSH-MS) was synthesized by free-radical polymerization for both haemostasis and antibacterial use. The as-prepared CSH-MS has a rough surface, and its water absorption is approximately 5000%. The resultant CSH-MS1 could promote blood cell aggregation and facilitate plasma protein activation via haemadsorption, resulting in efficient blood clot formation. Furthermore, CSH-MS1 (with approximately 5.06% contents of MS) dramatically reduces bleeding time and reduces blood loss in a rat-tail amputation model. Moreover, the CSH-MSs exhibits good antibacterial activities, excellent cytocompatibility and negligible haemolysis. Therefore, CSH-MS can serve as a novel type of haemostatic material in clinical applications.

控制大量出血及其相关的伤口感染是军事和平民创伤中心的主要挑战。在这项研究中，通过自由基聚合反应合成了具有介孔二氧化硅（CSH-MS）的阳离子超吸收性水凝胶，用于止血和抗菌。所制备的CSH-MS表面粗糙，吸水率约为5000％。生成的CSH-MS1可以促进血液细胞聚集并通过溶血作用促进血浆蛋白活化，从而导致有效的血凝块形成。此外，在鼠尾截肢模型中，CSH-MS1（MS含量约为5.06％）可大大减少出血时间并减少失血量。此外，CSH-MS具有良好的抗菌活性，优异的细胞相容性和可忽略不计的溶血作用。因此，