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Wnt-regulating microRNAs role in gastric cancer malignancy.
Life Sciences ( IF 5.2 ) Pub Date : 2020-03-12 , DOI: 10.1016/j.lfs.2020.117547 Milad Ashrafizadeh 1 , Hossein Rafiei 2 , Reza Mohammadinejad 3 , Tahereh Farkhondeh 4 , Saeed Samarghandian 5
Life Sciences ( IF 5.2 ) Pub Date : 2020-03-12 , DOI: 10.1016/j.lfs.2020.117547 Milad Ashrafizadeh 1 , Hossein Rafiei 2 , Reza Mohammadinejad 3 , Tahereh Farkhondeh 4 , Saeed Samarghandian 5
Affiliation
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Gastric cancer (GC) is responsible for high morbidity and mortality worldwide. This cancer claims fifth place among other cancers. There are a number of factors associated with GC development such as alcohol consumption and tobacco smoking. It seems that genetic factors play significant role in GC malignancy and progression. MicroRNAs (miRs) are short non-coding RNA molecules with negative impact on the expression of target genes. A variety of studies have elucidated the potential role of miRs in GC growth. Investigation of molecular pathways has revealed that miRs function as upstream modulators of Wnt signaling pathway. This signaling pathway involves in important biological processes such as cell proliferation and differentiation, and its dysregulation is associated with GC invasion. At the present review, we demonstrate that how miRs regulate Wnt signaling pathway in GC malignancy.
中文翻译：
Wnt调节microRNA在胃癌恶性肿瘤中的作用。
胃癌（GC）是导致全球高发病率和高死亡率的原因。该癌症在其他癌症中名列第五。与GC发展相关的因素很多，例如饮酒和吸烟。遗传因素似乎在GC恶性肿瘤和进展中起着重要作用。MicroRNA（miRs）是短的非编码RNA分子，对靶基因的表达产生负面影响。各种各样的研究阐明了miRs在GC生长中的潜在作用。分子途径的研究表明，miRs充当Wnt信号通路的上游调节剂。该信号通路涉及重要的生物学过程，例如细胞增殖和分化，并且其失调与GC入侵有关。在目前的审查中，
更新日期：2020-03-12
中文翻译：
Wnt调节microRNA在胃癌恶性肿瘤中的作用。
胃癌（GC）是导致全球高发病率和高死亡率的原因。该癌症在其他癌症中名列第五。与GC发展相关的因素很多，例如饮酒和吸烟。遗传因素似乎在GC恶性肿瘤和进展中起着重要作用。MicroRNA（miRs）是短的非编码RNA分子，对靶基因的表达产生负面影响。各种各样的研究阐明了miRs在GC生长中的潜在作用。分子途径的研究表明，miRs充当Wnt信号通路的上游调节剂。该信号通路涉及重要的生物学过程，例如细胞增殖和分化，并且其失调与GC入侵有关。在目前的审查中，
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