A new adduct of chaetoglobosin and aureonitol derivative, aureochaeglobosin D, with three new alkaloids cytoglobosin J-L were isolated from the solid culture of an endophytic Chaetomium globosum harbored in Pinellia ternata. The structures were elucidated by detailed spectroscopic analysis. Their absolute configurations were determined by the modified Mosher’s method and the Rh2(OCOCF3)4-induced electronic circular dichroism (ECD) experiment. These compounds exhibited moderate activities with IC50 values in the range of 11-37 µM when evaluating cytotoxic effects against MDA-MB-231, HepG2 and U-2OS cell lines. 2009 Elsevier Ltd. All rights reserved

从半夏的内生球藻壳虫的固体培养物中分离出一种新的chaetoglobosin和aureonitol衍生物，aureochaeglobosin D与三种新生物碱细胞球蛋白JL的加合物。通过详细的光谱分析阐明了结构。通过改进的Mosher方法和Rh2（OCOCF3）4诱导的电子圆二色性（ECD）实验确定了它们的绝对构型。当评估针对MDA-MB-231，HepG2和U-2OS细胞系的细胞毒性作用时，这些化合物表现出中等活性，IC50值在11-37 µM范围内。2009 Elsevier Ltd.保留所有权利