Control of Rubella and Congenital Rubella Syndrome using vaccination has shown great success in the America’s. Uganda is due to introduce the Rubella vaccine however the magnitude of transmission is not well documented. Therefore this study was done to determine IgM sero-prevalance for Rubella in order to help monitor vaccine effectiveness post introduction of the vaccine in routine vaccination programme. A retrospective review of suspected measles cases data for the reporting period January 2007 to December 2016 in Uganda was Done. rubella IgM testing was done on 15,296 of the cases and the data was analyzed using STATA version 13. In total 15,296 cases were tested and 4255 (27.8%) tested positive and among females aged 15-49 years 88 out of 322 (27%) tested positive. The age distribution range was 0–80 years, rubella IgM positivity was reported in all the 15 regions of Uganda and throughout the ten year period in every month. Age group 5–15 years had OR 2.5 p-value < 0.001 of being rubella IgM positive compared to age < 5 years and testing measles IgM negative OR 6.3 p-value < 0.001. Rubella is endemic in Uganda and although rubella IgM positivity is highest in the age 5-15 years even the younger, older and women of reprodutive age are affected. This means the risk of Congenital Rubella Syndrome is high hence the need to introduce the rubella vaccine for infants and pregnant mothers and continued surveillance to enhance its control.

中文翻译：

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乌干达风疹前疫苗接种时代的风疹IgM流行病学。

在美国，使用疫苗控制风疹和先天性风疹综合症已显示出巨大的成功。乌干达将引入风疹疫苗，但传播程度尚未得到充分记录。因此，本研究旨在确定风疹的IgM血清感染率，以帮助在常规疫苗接种计划中引入疫苗后监测疫苗有效性。完成了对乌干达2007年1月至2016年12月报告期麻疹病例数据的回顾性审查。在15296例病例中进行了风疹IgM检测，并使用STATA 13版对数据进行了分析。总共检测了15296例病例，其中4255例（27.8％）呈阳性，在15-49岁女性中，有322例中有88例（27％）测试阳性。年龄分布范围是0-80岁，在乌干达的所有15个地区以及每个月的十年期间，都报告了风疹IgM阳性。5至15岁年龄组的风疹IgM阳性的OR 2.5 p值<0.001，而小于5岁的年龄则为麻疹IgM阴性，或6.3 p值<0.001。风疹在乌干达很流行，尽管风疹IgM阳性率在5至15岁之间最高，但更年轻，年龄更大和生殖年龄的妇女也受到影响。这意味着先天性风疹综合症的风险很高，因此需要为婴儿和怀孕的母亲引入风疹疫苗，并需要持续监测以加强其控制。5年并检测麻疹IgM阴性或6.3 p值<0.001。风疹在乌干达很流行，尽管风疹IgM阳性率在5至15岁之间最高，但更年轻，年龄更大和生殖年龄的妇女也受到影响。这意味着先天性风疹综合症的风险很高，因此需要为婴儿和怀孕的母亲引入风疹疫苗，并需要持续监测以加强其控制。5年并检测麻疹IgM阴性或6.3 p值<0.001。风疹在乌干达很流行，尽管风疹IgM阳性率在5至15岁之间最高，但更年轻，年龄更大和生殖年龄的妇女也受到影响。这意味着先天性风疹综合症的风险很高，因此需要为婴儿和怀孕的母亲引入风疹疫苗，并需要持续监测以加强其控制。