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Lycopene Alleviates DSS-Induced Colitis and Behavioral Disorders via Mediating Microbes-Gut–Brain Axis Balance
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-03-23 , DOI: 10.1021/acs.jafc.0c00196 Beita Zhao 1 , Jianbin Wu 2 , Jinghao Li 2 , Yue Bai 2 , Yong Luo 2 , Bing Ji 2 , Bing Xia 2 , Zhigang Liu 2, 3 , Xintong Tan 4 , Jinyin Lv 1 , Xuebo Liu 2
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-03-23 , DOI: 10.1021/acs.jafc.0c00196 Beita Zhao 1 , Jianbin Wu 2 , Jinghao Li 2 , Yue Bai 2 , Yong Luo 2 , Bing Ji 2 , Bing Xia 2 , Zhigang Liu 2, 3 , Xintong Tan 4 , Jinyin Lv 1 , Xuebo Liu 2
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Gut microbes play significant roles in colitis development. The current study was aimed to uncover the preventive effects of lycopene (LYC), a functional carotenoid component, on colitis and the accompanied behavior disorders. The current study demonstrated that LYC treatment (50 mg/kg body weight/day) for 40 days prevented the dextran sulfate sodium (DSS)-induced gut barrier damages and inflammatory responses in male mice. LYC improved DSS-induced depression and anxiety-like behavioral disorders by suppressing neuroinflammation and prevented synaptic ultrastructure damages by upregulating the expressions of neurotrophic factor and postsynaptic-density protein. Moreover, LYC reshaped the gut microbiome in colitis mice by decreasing the relative abundance of proteobacteria and increasing the relative abundance ofBifidobacterium and Lactobacillus. LYC also elevated the generation of short-chain fatty acids and inhibited the permeability of lipopolysaccharide in colitis mice. In conclusion, LYC ameliorate DSS-induced colitis and behavioral disorders via mediating microbes–gut–brain axis balance.
中文翻译：
番茄红素通过介导微生物-肠-脑轴平衡减轻DSS诱导的结肠炎和行为障碍。
肠道微生物在结肠炎的发展中起重要作用。当前的研究旨在揭示番茄红素（LYC）（一种功能性类胡萝卜素成分）对结肠炎和伴随行为障碍的预防作用。当前的研究表明，LYC处理（50 mg / kg体重/天）持续40天可防止右旋硫酸钠（DSS）诱导的雄性小鼠肠道屏障损伤和炎症反应。LYC通过抑制神经炎症来改善DSS诱导的抑郁和焦虑样行为障碍，并通过上调神经营养因子和突触后密度蛋白的表达来防止突触超微结构损伤。此外，LYC通过降低蛋白质细菌的相对丰度和增加细菌的相对丰度来重塑结肠炎小鼠的肠道微生物组。双歧杆菌和乳酸菌。LYC还提高了短链脂肪酸的产生，并抑制了结肠炎小鼠中脂多糖的通透性。总之，LYC通过介导微生物-肠-脑轴平衡改善了DSS诱发的结肠炎和行为障碍。
更新日期：2020-03-24
中文翻译：
番茄红素通过介导微生物-肠-脑轴平衡减轻DSS诱导的结肠炎和行为障碍。
肠道微生物在结肠炎的发展中起重要作用。当前的研究旨在揭示番茄红素（LYC）（一种功能性类胡萝卜素成分）对结肠炎和伴随行为障碍的预防作用。当前的研究表明，LYC处理（50 mg / kg体重/天）持续40天可防止右旋硫酸钠（DSS）诱导的雄性小鼠肠道屏障损伤和炎症反应。LYC通过抑制神经炎症来改善DSS诱导的抑郁和焦虑样行为障碍，并通过上调神经营养因子和突触后密度蛋白的表达来防止突触超微结构损伤。此外，LYC通过降低蛋白质细菌的相对丰度和增加细菌的相对丰度来重塑结肠炎小鼠的肠道微生物组。双歧杆菌和乳酸菌。LYC还提高了短链脂肪酸的产生，并抑制了结肠炎小鼠中脂多糖的通透性。总之，LYC通过介导微生物-肠-脑轴平衡改善了DSS诱发的结肠炎和行为障碍。
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