Collimonas fungivorans Ter331 (CfTer331) is a soil bacterium that produces collimomycin, a secondary metabolite that inhibits the vegetative growth of fungi. Here we show that CfTer331 can also interfere with fungal spore germination and that collimomycin biosynthesis is required for this activity. More specifically, in co‐cultures of Aspergillus niger N402 (AnN402) co‐nidiospores with CfTer331, the rate of transition from the isotropic to polarized stage of the germination process was reduced and the relatively few AnN402 conidiospores that completed the germination process were less likely to survive than those that were arrested in the isotropic phase. By contrast, a collimomycin‐deficient mutant of CfTer331 had no effect on germination: in its presence, as in the absence or delayed presence of CfTer331, unhindered germination of conidiospores allowed rapid establishment of AnN402 mycelium and the subsequent acidification of the culture medium to the detriment of any bacteria present. However, when challenged early enough with CfTer331, the collimomycin‐dependent arrest of the AnN402 germination process enabled CfTer331 to prevent AnN402 from forming mycelia and to gain dominance in the culture. We propose that the collimomycin‐dependent arrest of spore germination represents an early intervention strategy used by CfTer331 to mitigate niche construction by fungi in nature.

中文翻译：

---

细菌产生的次生代谢产物科利霉素对黑曲霉孢子萌发的干扰。

Collimonas fungivorans Ter331（Cf Ter331）是一种土壤细菌，可产生collimomycin，后者是一种抑制真菌营养生长的次生代谢产物。在这里，我们显示Cf Ter331也可以干扰真菌的孢子萌发，而该活性需要科林霉素的生物合成。更具体地，在共培养物的黑曲霉N402（一种N402）共同nidiospores与比照Ter331，从各向同性的发芽过程的偏振阶段过渡的速率降低和相对较少的与在各向同性阶段被捕的那些相比，完成萌发过程的N402分生孢子的存活可能性较小。相比之下，一个collimomycin缺陷型突变比照Ter331对萌发无效果：在它的存在，为在不存在或延迟的存在比照Ter331，分生孢子的不受阻碍发芽允许迅速建立一个N402菌丝体和培养物的后续酸化有害于存在的任何细菌的培养基。然而，挑战足够早的时候比照Ter331的的collimomycin依赖逮捕的N402发芽过程中启用比照Ter331，以防止一个N402从形成菌丝体并在培养中获得优势。我们建议，依赖于霉素的孢子萌发的抑制作用是Cf Ter331用来减轻自然界真菌造成的生态位构建的一种早期干预策略。