Small animal irradiator dose distribution verification using radioluminescence imaging.,Journal of Biophotonics

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Small animal irradiator dose distribution verification using radioluminescence imaging.
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2020-04-07 , DOI: 10.1002/jbio.201960217
Antonello E Spinelli ₁ , Emilano D'Agostino ₂ , Sara Broggi ₃ , Fiorino Claudio ₃ , Federico Boschi ₄

Affiliation

The main objective of this work was the development of a novel 2D dosimetry approach for small animal external radiotherapy using radioluminescence imaging (RLI) with a commercial complementary metal oxide semiconductor detector. Measurements of RLI were performed on the small animal image‐guided platform SmART, RLI data were corrected for perspective distortion using Matlab. Four irradiation fields were tested and the planar 2D dose distributions and dose profiles were compared against dose calculations performed with a Monte Carlo based treatment planning system and gafchromic film. System linearity and RLI image noise against dose were also measured. The maximum difference between beam size measured with RLI and nominal beam size was less than 8% for all the tested beams. The image correction procedure was able to reduce perspective distortion. A novel RLI approach for quality assurance of a small animal irradiator was presented and tested. Results are in agreement with MC dose calculations and gafchromic film measurements.

中文翻译：

小动物辐照器剂量分布验证，使用放射荧光成像。

这项工作的主要目的是开发一种新颖的2D剂量学方法，用于小动物外部放射治疗，该方法采用带有商业互补金属氧化物半导体探测器的放射线成像（RLI）技术。RLI的测量是在小型动物影像引导平台SmART上进行的，使用Matlab对RLI数据进行了透视失真校正。测试了四个辐照场，并将平面2D剂量分布和剂量分布与使用基于Monte Carlo的治疗计划系统和前向变色膜进行的剂量计算进行了比较。还测量了系统线性度和相对于剂量的RLI图像噪声。对于所有测试光束，使用RLI测量的光束尺寸与标称光束尺寸之间的最大差值小于8％。图像校正程序能够减少透视失真。提出并测试了一种用于小型动物辐照器质量保证的新颖RLI方法。结果与MC剂量计算和全色膜测量结果一致。

更新日期：2020-04-07

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