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Polygenic multiple sclerosis risk and population-based childhood brain imaging.
Annals of Neurology ( IF 11.2 ) Pub Date : 2020-03-27 , DOI: 10.1002/ana.25717 C Louk de Mol 1, 2 , Philip R Jansen 1, 3, 4, 5, 6 , Ryan L Muetzel 1, 3 , Maria J Knol 7 , Hieab H Adams 5, 7, 8 , Vincent W Jaddoe 1, 9 , Meike W Vernooij 1, 5, 7 , Rogier Q Hintzen 2 , Tonya J White 3, 5 , Rinze F Neuteboom 2
Annals of Neurology ( IF 11.2 ) Pub Date : 2020-03-27 , DOI: 10.1002/ana.25717 C Louk de Mol 1, 2 , Philip R Jansen 1, 3, 4, 5, 6 , Ryan L Muetzel 1, 3 , Maria J Knol 7 , Hieab H Adams 5, 7, 8 , Vincent W Jaddoe 1, 9 , Meike W Vernooij 1, 5, 7 , Rogier Q Hintzen 2 , Tonya J White 3, 5 , Rinze F Neuteboom 2
Affiliation
Multiple sclerosis (MS) is a neurological disease with a substantial genetic component and immune‐mediated neurodegeneration. Patients with MS show structural brain differences relative to individuals without MS, including smaller regional volumes and alterations in white matter (WM) microstructure. Whether genetic risk for MS is associated with brain structure during early neurodevelopment remains unclear. In this study, we explore the association between MS polygenic risk scores (PRS) and brain imaging outcomes from a large, population‐based pediatric sample to gain insight into the underlying neurobiology of MS.
中文翻译:
多基因多发性硬化风险和基于人群的儿童脑成像。
多发性硬化症 (MS) 是一种神经系统疾病,具有大量遗传成分和免疫介导的神经变性。MS 患者相对于非 MS 患者表现出脑结构差异,包括较小的区域体积和白质 (WM) 微观结构的改变。MS 的遗传风险是否与早期神经发育过程中的大脑结构有关尚不清楚。在这项研究中,我们从基于人群的大型儿科样本中探索 MS 多基因风险评分 (PRS) 与脑成像结果之间的关联,以深入了解 MS 的潜在神经生物学。
更新日期:2020-03-27
中文翻译:
多基因多发性硬化风险和基于人群的儿童脑成像。
多发性硬化症 (MS) 是一种神经系统疾病,具有大量遗传成分和免疫介导的神经变性。MS 患者相对于非 MS 患者表现出脑结构差异,包括较小的区域体积和白质 (WM) 微观结构的改变。MS 的遗传风险是否与早期神经发育过程中的大脑结构有关尚不清楚。在这项研究中,我们从基于人群的大型儿科样本中探索 MS 多基因风险评分 (PRS) 与脑成像结果之间的关联,以深入了解 MS 的潜在神经生物学。