Advances in diverse diagnostic areas such as in vitro and molecular diagnoses have been stimulated by novel functional particles. In the industrialization stage of the diagnostic technology market, it is important to manufacture functional particles through low‐cost and large‐scale methods. Conventional methods in manufacturing magnetic particles typically involve modifying the surface of nano‐sized metal pieces with silica. These pieces are often suspended in a liquid state and difficult to separate, resulting in practical limitations during bioassay tests. A key factor in the manufacture of uniform magnetic particles is the mass production process. Herein, a new precision engineering method that focuses on rapid and cost‐effective mass production of uniform magnetic particles is presented, combining the cutting of magnetic microwires with electro‐opto‐micromachining techniques. The resulting giant magnetic glass‐coated particles have a high degree of uniformity and strong magnetic properties. They can be easily manipulated without the aid of a surfactant, and no particles are lost during bioassays. As biosensors, they offer high sensitivity and can be used in multiplexed immunoassays.

中文翻译：

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低成本大规模生产功能巨大的磁性玻璃涂层微粒作为免疫生物标记的精密工程新方法

新型功能性颗粒刺激了体外和分子诊断等各种诊断领域的进步。在诊断技术市场的工业化阶段，重要的是通过低成本和大规模的方法来制造功能颗粒。制造磁性颗粒的常规方法通常包括用二氧化硅修饰纳米级金属片的表面。这些碎片通常以液态悬浮并且难以分离，从而在生物测定测试中造成实际限制。制造均匀磁性颗粒的关键因素是批量生产过程。在此，提出了一种新的精密工程方法，该方法专注于快速且经济高效地批量生产均匀的磁性颗粒，将磁性微丝的切割与电光微加工技术相结合。所得的巨型磁性玻璃涂层颗粒具有高度的均匀性和强磁性。无需表面活性剂即可轻松操作它们，并且在生物测定过程中不会损失任何颗粒。作为生物传感器，它们具有很高的灵敏度，可用于多重免疫测定。