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Molecular principles of metastasis: a hallmark of cancer revisited.
Signal Transduction and Targeted Therapy ( IF 40.8 ) Pub Date : 2020-03-12 , DOI: 10.1038/s41392-020-0134-x
Jawad Fares 1, 2 , Mohamad Y Fares 3, 4 , Hussein H Khachfe 3, 4 , Hamza A Salhab 3, 4 , Youssef Fares 4
Affiliation  

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths. Yet, it remains poorly understood. The continuous evolution of cancer biology research and the emergence of new paradigms in the study of metastasis have revealed some of the molecular underpinnings of this dissemination process. The invading tumor cell, on its way to the target site, interacts with other proteins and cells. Recognition of these interactions improved the understanding of some of the biological principles of the metastatic cell that govern its mobility and plasticity. Communication with the tumor microenvironment allows invading cancer cells to overcome stromal challenges, settle, and colonize. These characteristics of cancer cells are driven by genetic and epigenetic modifications within the tumor cell itself and its microenvironment. Establishing the biological mechanisms of the metastatic process is crucial in finding open therapeutic windows for successful interventions. In this review, the authors explore the recent advancements in the field of metastasis and highlight the latest insights that contribute to shaping this hallmark of cancer.

中文翻译:

转移的分子原理:重新审视癌症的标志。

转移是癌症的标志,也是导致癌症相关死亡人数最多的原因。然而,人们对它仍然知之甚少。癌症生物学研究的不断发展和转移研究新范式的出现揭示了这一传播过程的一些分子基础。入侵的肿瘤细胞在到达目标部位的途中与其他蛋白质和细胞相互作用。对这些相互作用的认识增进了对转移细胞控制其移动性和可塑性的一些生物学原理的理解。与肿瘤微环境的通讯使入侵的癌细胞能够克服基质挑战、定居和定殖。癌细胞的这些特征是由肿瘤细胞本身及其微环境内的遗传和表观遗传修饰驱动的。建立转移过程的生物学机制对于寻找成功干预的开放治疗窗口至关重要。在这篇综述中,作者探讨了转移领域的最新进展,并强调了有助于塑造这一癌症标志的最新见解。
更新日期:2020-03-12
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