Abstract Brain delivery of drugs faces limitations due to the physiological and physical barriers. One of the strategies to overcome this problem is the use of nanotechnology in a pharmaceutical application. Carbohydrate polymer-based nanoparticles formed by polymerization of small length sugars, as a matrix material for drug delivery are more considered recently. Some of them like chitosan are mucoadhesive and can be used as a carrier in intranasal drug delivery to overcome the limitations of this route. Besides, carbohydrate polymers can enhance drug uptake by the brain. Surface-functionalized with endogenous substances like folic acid or some modifications on carbohydrate polymers can further improve site-specific drug delivery to the brain. Our review concludes that the carbohydrate-polymer nanoparticles as a drug delivery vehicle can be the ideal candidates for the remarkable improvement of both brain targeting and drug pharmacokinetics in the brain.

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基于碳水化合物聚合物的纳米粒子在中枢神经系统相关疾病药物递送中的应用

摘要 由于生理和物理障碍，药物的大脑输送面临限制。克服这个问题的策略之一是在药物应用中使用纳米技术。由小长度糖聚合形成的基于碳水化合物聚合物的纳米颗粒作为药物递送的基质材料最近被更多地考虑。其中一些如壳聚糖具有粘膜粘附性，可用作鼻内给药的载体以克服该途径的局限性。此外，碳水化合物聚合物可以增强大脑对药物的吸收。用叶酸等内源性物质或碳水化合物聚合物的一些修饰进行表面功能化，可以进一步改善特定部位的药物输送到大脑。