The centriole, or basal body, is the center of attachment between the sperm head and tail. While the distal end of the centriole templates the cilia, the proximal end associates with the nucleus. Using Drosophila, we identify a centriole-centric mechanism that ensures proper proximal end docking to the nucleus. This mechanism relies on the restriction of pericentrin-like protein (PLP) and the pericentriolar material (PCM) to the proximal end of the centriole. PLP is restricted proximally by limiting its mRNA and protein to the earliest stages of centriole elongation. Ectopic positioning of PLP to more distal portions of the centriole is sufficient to redistribute PCM and microtubules along the entire centriole length. This results in erroneous, lateral centriole docking to the nucleus, leading to spermatid decapitation as a result of a failure to form a stable head-tail linkage.

中文翻译：

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精子的头尾连接需要限制周脑材料到近端中心末端。

中心体或基体是精子头和尾巴之间附着的中心。当中心粒的远端模板纤毛时，近端与细胞核结合。使用果蝇，我们确定了以中心点为中心的机制，可确保适当的近端对接至核。这种机制依赖于束缚蛋白样蛋白（PLP）和束膜周围物质（PCM）限制在着丝粒的近端。通过将PLP的mRNA和蛋白质限制在中心粒伸长的最早阶段，可以限制PLP在近端。将PLP异位定位到中心粒的更多远端部分足以在整个中心粒长度上重新分布PCM和微管。这导致错误的侧向中心向核对接，