Background

The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public–private collaboration aiming to develop and test a system for rapid benefit-risk monitoring of vaccines using existing healthcare databases in Europe. We estimated vaccine coverage from electronic healthcare databases as part of a fit-for-purpose assessment for vaccine benefit-risk studies.

Methods

A retrospective dynamic cohort study was conducted through a distributed network approach. Coverage with measles-vaccine for birth year 2006, human papillomavirus (HPV)-vaccine for birth years 1990–2000 and influenza-vaccine for birth years 1920–1950 was estimated using period-prevalence and inverse probability weighting methods. Seven databases from four countries participated: Italy (Pedianet, Val Padana), Spain (BIFAP, SIDIAP), UK (RCGP-RSC, THIN), Denmark (SSI/AUH). Database access providers extracted the data, transformed it into a common structure and ran an R-script locally. The created output tables were shared and pooled at a central server.

Results

The total study population comprised 274,616 persons for measles-vaccine, 2,011,666 persons for HPV-vaccine and 14,904,033 persons for influenza-vaccine. Measles-vaccine coverage varied from 84.3% (Denmark) to 96.5% (Italy, Val Padana) for the first dose and from 82.8% (Italy, Val Padana) to 90.9% (UK) for the second dose at the age of 7 years. The HPV-vaccine coverage, aggregated over birth years 1997–2000, ranged from 60% (UK) to 88.3% (Denmark) at the age of 15 years. The influenza-vaccine coverage for the influenza seasons from 2009 to 2015 for persons aged 65 years and more was roughly stable around 43% in Denmark and around 68% in the UK while a decrease from 58 to 50% was observed in Catalonia (Spain).

Conclusions

We obtained detailed, age-specific coverage estimates though a common procedure. We discussed between database comparability and comparability to published national estimates.

中文翻译：

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来自四个欧盟国家/地区的七个基于人群的医疗数据库中针对流感，人乳头瘤病毒和包含疫苗的麻疹的按年龄划分的疫苗接种覆盖率估算-ADVANCE项目。

背景

欧洲VAccine利益风险协作的加速发展（ADVANCE）是一项公私合作项目，旨在使用欧洲现有的医疗数据库开发和测试用于疫苗的快速收益风险监测的系统。我们从电子医疗数据库中估算了疫苗的覆盖率，作为针对疫苗收益风险研究的针对性评估的一部分。

方法

通过分布式网络方法进行了回顾性动态队列研究。使用期间患病率和逆概率加权方法估算了2006年出生的麻疹疫苗，1990-2000年的人类乳头瘤病毒（HPV）疫苗和1920-1950年的流感疫苗的覆盖率。来自四个国家的七个数据库参加了会议：意大利（Pedianet，瓦尔帕达纳），西班牙（BIFAP，SIDIAP），英国（RCGP-RSC，THIN），丹麦（SSI / AUH）。数据库访问提供程序提取数据，将其转换为通用结构，然后在本地运行R脚本。创建的输出表被共享并集中在中央服务器上。

结果

The total study population comprised 274,616 persons for measles-vaccine, 2,011,666 persons for HPV-vaccine and 14,904,033 persons for influenza-vaccine. Measles-vaccine coverage varied from 84.3% (Denmark) to 96.5% (Italy, Val Padana) for the first dose and from 82.8% (Italy, Val Padana) to 90.9% (UK) for the second dose at the age of 7 years. The HPV-vaccine coverage, aggregated over birth years 1997–2000, ranged from 60% (UK) to 88.3% (Denmark) at the age of 15 years. The influenza-vaccine coverage for the influenza seasons from 2009 to 2015 for persons aged 65 years and more was roughly stable around 43% in Denmark and around 68% in the UK while a decrease from 58 to 50% was observed in Catalonia (Spain).

Conclusions

通过通用程序，我们获得了详细的，针对特定年龄段的覆盖率估计。我们讨论了数据库的可比性与已发布的国家估算的可比性。