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Application of 3D printed tools for customized open port probe-electrospray mass spectrometry.
Talanta ( IF 5.6 ) Pub Date : 2020-03-12 , DOI: 10.1016/j.talanta.2020.120894
Piotr Sosnowski 1 , Gérard Hopfgartner 1
Affiliation  

Three dimensional printed open port probe (3DP-OPP) and air displacement based liquid handler, were designed and optimized using fused deposition modeling (FDM) and stereolitography (SLA) 3D printing. The performance of the devices were investigated for the analysis of solid and liquid samples with electrospray ionization mass spectrometry (ESI-MS). Direct analysis in less than 1 min and without any sample preparation, enabled detection of pesticides (azoxtystrobin/imazalil) on fruits peel surface and illegal substances (MDMA/MDEA) in home-made pills. Conjunction of OPP in the overspill mode with a customized autosampler, equipped with disposable pipette tips, enables direct quantitative analysis of drugs of abuse in urine and plasma, with minimized carry-over and reduced matrix effect compared to flow injection analysis.

中文翻译:

3D打印工具在定制开放端口探针-电喷雾质谱分析中的应用。

使用熔融沉积建模(FDM)和立体光刻(SLA)3D打印来设计和优化三维打印的开放式端口探针(3DP-OPP)和基于空气排量的液体处理器。研究了该设备的性能,以利用电喷雾电离质谱(ESI-MS)分析固体和液体样品。在不到1分钟的时间内进行直接分析并且无需任何样品前处理,就可以检测果皮表面上的农药(偶氮唑菌酯/伊马替利)和自制药丸中的非法物质(MDMA / MDEA)。与溢流模式配合使用的OPP与定制的自动进样器一起使用,该自动进样器配备有一次性移液器吸头,可对尿液和血浆中的滥用药物进行直接定量分析,与流动注射分析相比,残留物减少了,基质效应降低了。
更新日期:2020-03-12
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