Recurrent chest pain episodes with no clear explanation may affect patients’ psychological wellbeing and health-related quality of life (HRQoL) negatively. Despite the fact that a significant amount of patients with non-cardiac chest pain (NCCP) might have a history of Cardiac Disease (CD), there is today a lack of knowledge on how CD influences the association between psychological wellbeing and HRQoL in patients with NCCP. Therefore, the aim of this study is to describe HRQoL in patients with NCCP, with or without history of CD, and to explore the association between HRQoL and cardiac anxiety, depressive symptoms, fear of body sensations and somatization. Five hundred fifty-two patients discharged with NCCP from four hospitals in Southeast Sweden completed the EQ-5D, Cardiac Anxiety Questionnaire, Patient Health Questionnaire-9, Body Sensations Questionnaire, and Patient Health Questionnaire-15. Fifty precent reported at least moderate problems regarding pain/discomfort and 25% reported at least moderate problems in the HRQoL dimensions mobility, usual activities, and anxiety/depression. Patients with NCCP and history of CD reported significantly lower HRQoL (p ≤ 0.05) compared to patients with NCCP without CD. In the total study population, cardiac anxiety, depressive symptoms, and somatization had weak significant negative associations (beta = 0.187–0.284, p < 0.001) with HRQoL. In patients with history of CD, the association between depressive symptoms and HRQoL was moderate (beta = − 0.339, p < 0.001), compared to weak association in patients without CD (beta = − 0.193, p < 0.001). On the other hand, the association between cardiac anxiety and HRQoL was weak in both patients with history of CD (beta = − 0.156, p = 0.05), and in those without (beta = − 0.229, p < 0.001). Patients with NCCP, in particular those with history of CD, reported low levels of HRQoL, which was associated with psychological distress. This should be considered when developing psychological interventions aiming to improve HRQoL in patients with NCCP.

中文翻译：

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非心源性胸痛患者的心理困扰与健康相关的生活质量之间的关系。

没有明确解释的复发性胸痛发作可能会对患者的心理健康和与健康相关的生活质量（HRQoL）产生负面影响。尽管事实上有大量非心源性胸痛（NCCP）患者可能有心脏病（CD）病史，但如今仍缺乏关于CD如何影响精神病患者心理健康与HRQoL关联的知识。 NCCP。因此，本研究的目的是描述患有或没有CD病史的NCCP患者的HRQoL，并探讨HRQoL与心脏焦虑，抑郁症状，对身体感觉的恐惧和躯体化之间的关系。来自瑞典东南部四家医院的252名因NCCP出院的患者完成了EQ-5D，心脏焦虑问卷，患者健康问卷9，身体感觉问卷和患者健康问卷15。百分之五十的人至少在疼痛/不适方面有中度问题，百分之二十五的人在HRQoL维度的活动能力，日常活动和焦虑/抑郁方面至少有中度问题。与没有CD的NCCP患者相比，具有NCCP和CD病史的患者报告HRQoL显着降低（p≤0.05）。在全部研究人群中，心脏焦虑，抑郁症状和躯体化与HRQoL之间存在弱的显着负相关性（β= 0.187-0.284，p <0.001）。在有CD史的患者中，抑郁症状与HRQoL之间的关联为中度（β= − 0.339，p <0.001），而在没有CD的患者中则为弱关联（beta = − 0.193，p <0.001）。另一方面，CD病史的患者（β= − 0.156，p = 0.05）和无CD病史的患者（β= − 0.229，p <0.001）之间的心脏焦虑与HRQoL之间的关联均较弱。NCCP患者，尤其是有CD史的患者，其HRQoL水平较低，这与心理困扰有关。在制定旨在改善NCCP患者的HRQoL的心理干预措施时应考虑这一点。