Meniscal allograft transplantation (MAT) may improve symptoms and function, and may limit premature knee degeneration in patients with symptomatic meniscal loss. The aim of this retrospective study was to examine patient outcomes after MAT and to explore the different potential definitions of ‘success’ and ‘failure’. Sixty patients who underwent MAT between 2008 and 2014, aged 18–50 were identified. Six validated outcome measures for knee pathologies, patient satisfaction and return to sport were incorporated into a questionnaire. Surgical failure (removal of most/all the graft, revision MAT or conversion to arthroplasty), clinical failure (Lysholm < 65), complication rates (surgical failure plus repeat arthroscopy for secondary allograft tears) and whether patients would have the procedure again were recorded. Statistics analysis included descriptive statistics, with patient-reported outcome measures reported as median and range. A binomial logistic regression was performed to assess factors contributing to failure. Forty-three patients (72%) responded, mean age 35.6 (±7.5). 72% required concomitant procedures, and 44% had Outerbridge III or IV chondral damage. The complication rate was 21% (9). At mean follow-up of 3.4 (±1.6) years, 9% (4) were surgical failures and 21% (9) were clinical failures. Half of those patients considered a failure stated they would undergo MAT again. In the 74% (32) reporting they would undergo MAT again, median KOOS, IKDC and Lysholm scores were 82.1, 62.1 and 88, compared to 62.2, 48.5 and 64 in patients who said they would not. None of the risk factors significantly contributed to surgical or clinical failure, although female gender and number of concomitant procedures were nearly significant. Following MAT, 40% were dissatisfied with type/level of sport achieved, but only 14% would not consider MAT again. None of the risk factors examined were linked to surgical or clinical failure. Whilst less favourable outcomes are seen with Outerbridge Grade IV, these patients should not be excluded from potential MAT. Inability to return to sport is not associated with failure since 73% of these patients would undergo MAT again. The disparity between ‘clinical failure’ and ‘surgical failure’ outcomes means these terms may need re-defining using a specific/bespoke MAT scoring system.

中文翻译：

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半月板同种异体移植手术的结果：成功是什么？

半月板同种异体移植（MAT）可能会改善症状和功能，并可能限制有症状半月板缺失患者的膝盖过早变性。这项回顾性研究的目的是检查MAT后的患者预后，并探讨“成功”和“失败”的不同潜在定义。确定了2008年至2014年间接受MAT治疗的60位年龄在18至50岁之间的患者。问卷中纳入了六种经过验证的关于膝关节病理，患者满意度和运动恢复的结果指标。记录手术失败（去除大部分/所有移植物，修订MAT或改成人工关节置换术），临床失败（Lysholm <65），并发症发生率（手术失败加上重复的关节镜检查以继发同种异体移植眼泪）以及患者是否再次进行手术。统计分析包括描述性统计，患者报告的结局指标为中位数和范围。进行二项逻辑回归分析以评估导致失败的因素。四十三名患者（72％）有反应，平均年龄35.6（±7.5）。72％的患者需要进行相应的手术，而44％的患者患有Outerbridge III或IV软骨损伤。并发症发生率为21％（9）。平均随访3.4（±1.6）年，手术失败占9％（4），临床失败占21％（9）。那些认为失败的患者中有一半表示他们将再次接受MAT。在74％（32）的报告中，他们将再次接受MAT，KOOS，IKDC和Lysholm得分的中位数分别为82.1、62.1和88，相比之下，表示不参加的患者分别为62.2、48.5和64。没有任何危险因素会明显导致手术或临床失败，尽管女性和随之而来的手术数量几乎是重要的。参加MAT后，有40％的人对所达到的运动类型/水平不满意，但只有14％的人不再考虑MAT。没有检查到的危险因素与手术或临床失败有关。尽管Outerbridge IV级患者的预后较差，但不应将这些患者排除在潜在的MAT之外。无法恢复运动与失败无关，因为这些患者中有73％会再次接受MAT。“临床失败”和“手术失败”结果之间的差异意味着这些术语可能需要使用特定的/定制的MAT评分系统进行重新定义。但只有14％的人不会再考虑MAT。没有检查到的危险因素与手术或临床失败有关。尽管Outerbridge IV级患者的预后较差，但不应将这些患者排除在潜在的MAT之外。无法恢复运动与失败无关，因为这些患者中有73％会再次接受MAT。“临床失败”和“手术失败”结果之间的差异意味着这些术语可能需要使用特定的/定制的MAT评分系统进行重新定义。但只有14％的人不会再考虑MAT。没有检查到的危险因素与手术或临床失败有关。尽管Outerbridge IV级患者的预后较差，但不应将这些患者排除在潜在的MAT之外。无法恢复运动与失败无关，因为这些患者中有73％会再次接受MAT。“临床失败”和“手术失败”结果之间的差异意味着这些术语可能需要使用特定的/定制的MAT评分系统进行重新定义。