Inflammation-related parameters have been revealed to have prognostic value in multiple caners. However, the significance of some inflammation-related parameters, including the peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and prognostic nutritional index (PNI), remains controversial in T1–2 rectal cancer (RC). Clinical data of 154 T1–2 RC patients were retrospectively reviewed. The cut-off values for NLR, PLR, LMR, and PNI were determined by receiver operating characteristic curves. The relationships of these parameters with postoperative morbidities and prognosis were statistically analysed. The optimal cut-off values for preoperative NLR, PLR, LMR and PNI were 2.8, 140.0, 3.9, and 47.1, respectively. Significant but heterogeneous associations were found between NLR, PLR, LMR and PNI and clinicopathological factors. In addition, high NLR, high PLR, and low PNI were correlated with an increased postoperative morbidity rate. Patients with high NLR/PLR or low LMR/PNI had lower OS and DFS rates. On multivariate analysis, only high NLR was identified as an independent risk factor for poor DFS. NLR, PLR, and PNI are valuable factors for predicting postoperative complications in T1–2 RC patients. A preoperative NLR of more than 2.8 is an independent prognostic factor for poor DFS in T1–2 RC patients.

中文翻译：

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中性粒细胞与淋巴细胞的比率，血小板与淋巴细胞的比率，淋巴细胞与单核细胞的比率以及预后营养指数对预测T1-2直肠癌临床结局的意义

炎症相关参数已被证实对多发性结肠癌具有预后价值。但是，某些炎症相关参数的意义包括外周血中性粒细胞与淋巴细胞之比（NLR），血小板与淋巴细胞之比（PLR），淋巴细胞与单核细胞之比（LMR）和预后营养指数（PNI） ）在T1-2直肠癌（RC）中仍存在争议。回顾性分析了154例T1-2 RC患者的临床资料。NLR，PLR，LMR和PNI的截止值由接收器工作特性曲线确定。对这些参数与术后发病率和预后的关系进行统计学分析。术前NLR，PLR，LMR和PNI的最佳临界值分别为2.8、140.0、3.9和47.1。在NLR之间发现了重要但异类的关联，PLR，LMR和PNI以及临床病理因素。另外，高NLR，高PLR和低PNI与术后发病率增加相关。NLR / PLR高或LMR / PNI低的患者的OS和DFS率较低。在多变量分析中，只有高的NLR被确定为不良DFS的独立危险因素。NLR，PLR和PNI是预测T1-2 RC患者术后并发症的重要因素。T1–2 RC患者的术前NLR大于2.8是DFS不良的独立预后因素。只有高的NLR被确定为不良DFS的独立危险因素。NLR，PLR和PNI是预测T1-2 RC患者术后并发症的重要因素。T1–2 RC患者的术前NLR大于2.8是DFS不良的独立预后因素。只有高的NLR被确定为不良DFS的独立危险因素。NLR，PLR和PNI是预测T1-2 RC患者术后并发症的重要因素。T1–2 RC患者的术前NLR大于2.8是DFS不良的独立预后因素。