Rhodium-Catalyzed C(sp2)–H Amidation of Azine with Sulfonamides,The Journal of Organic Chemistry

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Rhodium-Catalyzed C(sp2)–H Amidation of Azine with Sulfonamides
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-03-20 , DOI: 10.1021/acs.joc.0c00138
Huu-Manh Vu ₁ , Jia-Yuan Yong ₁ , Fei-Wu Chen ₁ , Xu-Qin Li ₁ , Guo-Qing Shi ₁

Affiliation

Direct C–H amidation of azine with sulfonamide was developed for the first time. The reactions proceeded smoothly under benign conditions and gave the corresponding products with high selectivity. This approach shows high regioselectivity, wide substrate scope, and functional group tolerance. Additionally, this transformation can also be scaled up to the gram level. This strategy allows for the direct preparation of ortho-sulfonamide-substituted ketone products, thus providing a good complement to previous C–H amidation.

中文翻译：

铑催化的磺胺酰胺化C（sp ²）–H酰胺化

首次开发了将磺酰胺直接用CH酰胺酰胺化的方法。反应在良性条件下顺利进行，并得到具有高选择性的相应产物。这种方法显示出较高的区域选择性，较宽的底物范围和官能团耐受性。另外，此变换也可以按比例放大到克级。该策略可直接制备邻磺酰胺取代的酮产品，从而为以前的CH酰胺化提供了良好的补充。

更新日期：2020-03-21

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