Selective killing of leukemia cells: Yamanaka factors’ new trick,STEM CELLS

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Selective killing of leukemia cells: Yamanaka factors’ new trick
STEM CELLS ( IF 4.0 ) Pub Date : 2020-03-20 , DOI: 10.1002/stem.3173
Huafeng Xie _{1,

2,

3} , Thomas Graf _{4,

5,

6}

Affiliation

The four transcription factors of the Yamanaka cocktail (Oct4, Sox2, Klf4, and Myc, termed OSKM) are famously capable of reprogramming somatic cells into induced pluripotent stem cells (iPSCs). In an article recently published in Nature Communications, Wang et al describe the unexpected discovery that short‐term activation of OSKM expression in acute myeloid leukemia cells in vivo induces apoptosis while negligibly affecting normal hematopoietic stem and progenitor cells (Nat Commun 2019;10:5594). These findings have potential implications for novel anticancer strategies.

中文翻译：

选择性杀伤白血病细胞：山中因子的新把戏

众所周知，山中鸡尾酒的四种转录因子（Oct4、Sox2、Klf4 和 Myc，称为 OSKM）能够将体细胞重编程为诱导多能干细胞 (iPSC)。在最近发表在 Nature Communications 上的一篇文章中，Wang 等人描述了一个意外发现，即在体内急性髓性白血病细胞中 OSKM 表达的短期激活诱导细胞凋亡，而对正常造血干细胞和祖细胞的影响可忽略不计（Nat Commun 2019;10:5594 ）。这些发现对新的抗癌策略具有潜在意义。

更新日期：2020-03-20

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