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Organic Spherical Nucleic Acids for the Transport of a NIR-II-Emitting Dye Across the Blood-Brain Barrier.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-03-11 , DOI: 10.1002/anie.202002312 Fan Xiao 1, 2 , Lin Lin 3, 4 , Zhicong Chao 1 , Chen Shao 1 , Zhe Chen 1 , Zixiang Wei 1 , Jingxiong Lu 1, 5 , Yishun Huang 1 , Lanqing Li 1 , Quan Liu 3 , Yongye Liang 1 , Leilei Tian 1
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-03-11 , DOI: 10.1002/anie.202002312 Fan Xiao 1, 2 , Lin Lin 3, 4 , Zhicong Chao 1 , Chen Shao 1 , Zhe Chen 1 , Zixiang Wei 1 , Jingxiong Lu 1, 5 , Yishun Huang 1 , Lanqing Li 1 , Quan Liu 3 , Yongye Liang 1 , Leilei Tian 1
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DNA nanotechnology plays an increasingly important role in the biomedical field; however, its application in the design of organic nanomaterials is underexplored. Herein, we report the use of DNA nanotechnology to transport a NIR‐II‐emitting nanofluorophore across the blood–brain barrier (BBB), facilitating non‐invasive imaging of brain tumors. Specifically, the DNA block copolymer, PS‐b ‐DNA, is synthesized through a solid‐phase click reaction. We demonstrate that its self‐assembled structure shows exceptional cluster effects, among which BBB‐crossing is the most notable. Therefore, PS‐b ‐DNA is utilized as an amphiphilic matrix to fabricate a NIR‐II nanofluorephore, which is applied in in vivo bioimaging. Accordingly, the NIR‐II fluorescence signal of the DNA‐based nanofluorophore localized at a glioblastoma is 3.8‐fold higher than the NIR‐II fluorescence signal of the PEG‐based counterpart. The notably increased imaging resolution will significantly benefit the further diagnosis and therapy of brain tumors.
中文翻译：
NIR-II发射染料跨血脑屏障运输的有机球形核酸。
DNA纳米技术在生物医学领域起着越来越重要的作用。然而，其在有机纳米材料设计中的应用尚未得到充分的研究。在本文中，我们报道了使用DNA纳米技术跨血脑屏障（BBB）转运发射NIR-II的纳米荧光团，促进了脑肿瘤的非侵入性成像。特别是，DNA嵌段共聚物PS- b - DNA是通过固相点击反应合成的。我们证明了其自组装结构表现出出众的簇效应，其中BBB穿越最为显着。因此，PS‐ b‐DNA被用作两亲基质来制造NIR-II纳米荧光团，并用于体内生物成像。因此，位于胶质母细胞瘤中的基于DNA的纳米荧光团的NIR-II荧光信号比基于PEG的对应物的NIR-II荧光信号高3.8倍。显着提高的成像分辨率将大大有利于脑肿瘤的进一步诊断和治疗。
更新日期：2020-03-11
中文翻译：
NIR-II发射染料跨血脑屏障运输的有机球形核酸。
DNA纳米技术在生物医学领域起着越来越重要的作用。然而，其在有机纳米材料设计中的应用尚未得到充分的研究。在本文中，我们报道了使用DNA纳米技术跨血脑屏障（BBB）转运发射NIR-II的纳米荧光团，促进了脑肿瘤的非侵入性成像。特别是，DNA嵌段共聚物PS- b - DNA是通过固相点击反应合成的。我们证明了其自组装结构表现出出众的簇效应，其中BBB穿越最为显着。因此，PS‐ b‐DNA被用作两亲基质来制造NIR-II纳米荧光团，并用于体内生物成像。因此，位于胶质母细胞瘤中的基于DNA的纳米荧光团的NIR-II荧光信号比基于PEG的对应物的NIR-II荧光信号高3.8倍。显着提高的成像分辨率将大大有利于脑肿瘤的进一步诊断和治疗。
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