Solid–fluid transition and cell sorting in epithelia with junctional tension fluctuations,Soft Matter

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Solid–fluid transition and cell sorting in epithelia with junctional tension fluctuations
Soft Matter ( IF 2.9 ) Pub Date : 2020/03/11 , DOI: 10.1039/c9sm02310k
Matej Krajnc _{1,

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Affiliation

Tissues transition between solid-like and fluid-like behavior, which has major implications for morphogenesis and disease. These transitions can occur due to changes in the intrinsic shape of constituent cells and cell motility. We consider an alternative mechanism by studying tissues that explore the energy landscape through stochastic dynamics, driven by turnover of junctional molecular motors. To identify the solid–fluid transition, we start with single-component tissues and show that the mean cell-shape index uniquely describes the effective diffusion coefficient of cell movements, which becomes finite at the transition. We generalize our approach to two-component tissues, and explore cell-sorting dynamics both due to differential adhesion and due to differential degree of junctional fluctuations. We recover some known characteristic scaling relations describing the sorting kinetics, and discover some discrepancies from these relations in the case of differential-fluctuations-driven sorting. Finally, we show that differential fluctuations efficiently sort two solid-like tissues with a fluid intercompartmental boundary.

中文翻译：

具有连接张力波动的上皮中的固液过渡和细胞分选

组织在固体行为和液体行为之间过渡，这对形态发生和疾病具有重要意义。由于组成细胞的固有形状和细胞运动性的变化，可能发生这些转变。我们通过研究组织中的一种替代机制来研究这种组织，该组织通过由交界分子马达的周转驱动的随机动力学来探索能量格局。为了确定固-液过渡，我们从单组分组织开始，并表明平均细胞形状指数唯一描述了细胞运动的有效扩散系数，该系数在过渡时变得有限。我们将我们的方法推广到两组分组织，并探讨由于不同的粘附力和不同程度的连接波动而引起的细胞分选动力学。我们恢复了描述分选动力学的一些已知特征比例关系，并在微分涨落驱动的分选情况下从这些关系中发现了一些差异。最后，我们证明了微分涨落有效地将两个实体状组织与一个流体隔室边界进行了排序。

更新日期：2020-04-01

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