Chelation-assisted transition metal-catalysed C–H chalcogenylations,Organic Chemistry Frontiers

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Chelation-assisted transition metal-catalysed C–H chalcogenylations
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-03-11 , DOI: 10.1039/c9qo01497g
Wenbo Ma _{1,

2,

3,

4,

5} , Nikolaos Kaplaneris _{6,

7,

8,

9} , Xinyue Fang _{1,

2,

3,

4,

5} , Linghui Gu _{1,

2,

3,

4,

5} , Ruhuai Mei _{4,

5,

10} , Lutz Ackermann _{6,

7,

8,

9}

Affiliation

The development of convenient and mild chalcogenylation reactions for the preparation of unsymmetrical diaryl sulfides and diaryl selenides has received significant attention in recent years due to their prevalence in natural products, organic molecular syntheses, catalysis, drug candidates and functional materials. In contrast with conventional organic transformations which largely rely on the inherent reactivity of functional groups, transition metal-catalysed direct C–H functionalizations have emerged as a powerful strategy that eliminates prefunctionalised starting materials and thus leads to more atom- and step-economical processes. This review summarizes the recent advances in C–S and C–Se formations via transition metal-catalyzed C–H functionalization utilizing directing groups to control the site-selectivity until autumn 2019. Typical examples are listed and mechanistic aspects are discussed in detail.

中文翻译：

螯合辅助过渡金属催化的CH硫属元素化

近年来，由于不对称二芳基硫和二芳基硒化物在天然产物，有机分子合成，催化作用，候选药物和功能材料中的普遍使用，方便而温和的硫属化合物化反应的开发受到了广泛的关注。与主要依赖于官能团固有反应性的常规有机转化相反，过渡金属催化的直接C–H官能化已成为一种强大的策略，它消除了预官能化的起始原料，从而导致了更多的原子经济和阶梯经济的过程。本文总结了C-S和C-硒地层中的最新进展通过过渡金属催化的C–H功能化，利用导向基团控制位点选择性，直至2019年秋季。列出了典型实例，并对机理进行了详细讨论。

更新日期：2020-04-24

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