Single-cell sequencing (SCS) data provide unprecedented insights into intratumoral heterogeneity. With SCS, we can better characterize clonal genotypes and reconstruct phylogenetic relationships of tumor cells/clones. However, SCS data are often error-prone, making their computational analysis challenging.

中文翻译：

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RobustClone：一种健壮的PCA方法，用于从单细胞测序数据进行肿瘤克隆和进化推断。

单细胞测序（SCS）数据为肿瘤内异质性提供了前所未有的见识。使用SCS，我们可以更好地表征克隆基因型并重建肿瘤细胞/克隆的系统发生关系。但是，SCS数据通常容易出错，从而使其计算分析更具挑战性。