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RobustClone: a robust PCA method for tumor clone and evolution inference from single-cell sequencing data.
Bioinformatics ( IF 4.4 ) Pub Date : 2020-03-11 , DOI: 10.1093/bioinformatics/btaa172
Ziwei Chen 1, 2 , Fuzhou Gong 1, 2 , Lin Wan 1, 2 , Liang Ma 3
Affiliation  

Single-cell sequencing (SCS) data provide unprecedented insights into intratumoral heterogeneity. With SCS, we can better characterize clonal genotypes and reconstruct phylogenetic relationships of tumor cells/clones. However, SCS data are often error-prone, making their computational analysis challenging.

中文翻译:

RobustClone:一种健壮的PCA方法,用于从单细胞测序数据进行肿瘤克隆和进化推断。

单细胞测序(SCS)数据为肿瘤内异质性提供了前所未有的见识。使用SCS,我们可以更好地表征克隆基因型并重建肿瘤细胞/克隆的系统发生关系。但是,SCS数据通常容易出错,从而使其计算分析更具挑战性。
更新日期:2020-03-11
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