Three decades ago, the schizophrenia field finally began to challenge the intrinsic pessimism that had inhibited preventive approaches for a century. Early detection and specialized early treatment models for first-episode psychosis have since become the global standard of care, producing better outcomes that “bend the curve” of the early course of illness¹ and have opened the door to the prevention or delay of the first episode of psychosis. The development of operational criteria (the “ultra” or “clinical” high risk [CHR] criteria) for identifying what we originally termed the at-risk mental state meant that an even earlier stage of illness could be identified prospectively and studied for its heuristic and therapeutic potential.

三十年前，精神分裂症领域终于开始挑战固有的悲观主义，这种悲观主义抑制了一个世纪的预防方法。此后，针对首发性精神病的早期发现和专门的早期治疗模型已成为全球护理标准，产生了更好的结果，“弯曲”了疾病的早期进程^1，并为预防或延缓首发疾病打开了大门。精神病发作。用于确定我们最初称为处于危险状态的精神状态的操作标准（“超”或“临床”高风险[CHR]标准）的开发意味着可以对疾病的更早期阶段进行前瞻性识别并对其启发式进行研究和治疗潜力。