Flavonoids are natural compounds defined as plant secondary metabolites with various beneficial properties for human health that make them perspective drug candidates. However, research in this area should be deepened to collect reasonable amount of data to suggest biochemical mechanism of action that can be a key for evaluation of drug efficacy, side effects. In addition, from analytical point of view, analyte-receptor interaction is an interesting object for study as it includes challenges in sample preparation and analytical measurements. Thus, there is a need in modern instrumental analytical techniques for study of drug-receptor interactions. Combination of instrumental techniques represents multi-instrumental approach and provides an extended set of data to suggest mechanism and to evaluate changes in initial biological activity caused by interaction. Current review is focused on advances and limitations of multi-instrumental approach and analytical techniques for study of flavonoid-receptor interactions and insights into molecular mechanisms of flavonoids.

黄酮类化合物是定义为植物次生代谢产物的天然化合物，对人体健康具有多种有益特性，使它们成为候选药物。但是，应加深该领域的研究，以收集合理数量的数据，以提出可能是评估药物功效和副作用的关键的生化作用机制。此外，从分析的角度来看，分析物与受体的相互作用是一个有趣的研究对象，因为它在样品制备和分析测量中存在挑战。因此，需要现代的仪器分析技术来研究药物-受体相互作用。仪器技术的结合代表了多种仪器方法，并提供了扩展的数据集，以提示机理并评估由相互作用引起的初始生物活性的变化。当前的审查集中在研究类黄酮-受体相互作用的多仪器方法和分析技术的进步与局限性以及对类黄酮分子机制的见解。