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Cognitive functioning in ultra-high risk for psychosis individuals with and without depression: Secondary analysis of findings from the NEURAPRO randomized clinical trial
Schizophrenia Research ( IF 3.6 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.schres.2020.03.008
Sumudu Rasangi Mallawaarachchi 1 , G Paul Amminger 2 , John Farhall 3 , Luke K Bolt 3 , Barnaby Nelson 4 , Hok Pan Yuen 1 , Patrick D McGorry 1 , Connie Markulev 1 , Miriam R Schäfer 5 , Nilufar Mossaheb 6 , Monika Schlögelhofer 6 , Stefan Smesny 7 , Ian B Hickie 8 , Gregor Emanuel Berger 9 , Eric Y H Chen 10 , Lieuwe de Haan 11 , Dorien H Nieman 11 , Merete Nordentoft 12 , Anita Riecher-Rössler 13 , Swapna Verma 14 , Andrew Thompson 15 , Alison Ruth Yung 16 , Kelly A Allott 1
Affiliation  

Neurocognitive impairments are well established in both ultra-high risk (UHR) for psychosis and major depressive disorder (MDD). Despite this understanding, investigation of neurocognitive deficits in UHR individuals with MDD and its association with MDD within this population, has been scarce. Hence, this study aimed to examine any differences in neurocognition at baseline between those with MDD at baseline and those with no history of MDD, as well as determine whether neurocognitive variables are significantly associated with meeting criteria for MDD at follow-up, while controlling for relevant clinical variables, within a UHR cohort. Data analysis was conducted on 207 participants whose baseline neurocognition was assessed using Brief Assessment of Cognition for Schizophrenia, as part of a trial of omega-3 fatty acids (NEURAPRO) for UHR individuals. While baseline MDD was the strongest predictor, poorer verbal memory and higher verbal fluency were significantly associated with MDD at 12 months (p = .04 and 0.026, respectively). Further, higher processing speed was significantly associated with MDD at medium-term follow-up (p = .047). These findings outline that neurocognitive skills were independently associated with meeting criteria for MDD at follow-up within UHR individuals, with novel findings of better verbal fluency and processing speed being linked to MDD outcomes. Hence, neurocognitive performance should be considered as a marker of risk for MDD outcomes and a target for management of MDD in UHR.

中文翻译:

患有和不患有抑郁症的精神病患者超高风险的认知功能:对 NEURAPRO 随机临床试验结果的二次分析

神经认知障碍在精神病的超高风险 (UHR) 和重度抑郁症 (MDD) 中均已确立。尽管有这种理解,但对患有 MDD 的 UHR 个体的神经认知缺陷及其与该人群中 MDD 的关联的调查一直很少。因此,本研究旨在检查基线时患有 MDD 的人和没有 MDD 病史的人之间在基线时的神经认知差异,并确定神经认知变量是否与随访时满足 MDD 的标准显着相关,同时控制UHR 队列中的相关临床变量。对 207 名参与者进行了数据分析,他们的基线神经认知使用精神分裂症的认知简要评估进行评估,作为针对 UHR 个人的 omega-3 脂肪酸 (NEURAPRO) 试验的一部分。虽然基线 MDD 是最强的预测因子,但较差的语言记忆和较高的语言流畅性与 12 个月时的 MDD 显着相关(分别为 p = .04 和 0.026)。此外,在中期随访中,较高的处理速度与 MDD 显着相关(p = .047)。这些发现概述了神经认知技能与 UHR 个体随访时满足 MDD 标准独立相关,而更好的语言流畅性和处理速度的新发现与 MDD 结果相关。因此,神经认知表现应被视为 MDD 结果风险的标志和 UHR 中 MDD 管理的目标。较差的语言记忆和较高的语言流畅性与 12 个月时的 MDD 显着相关(分别为 p = .04 和 0.026)。此外,在中期随访中,较高的处理速度与 MDD 显着相关(p = .047)。这些发现概述了神经认知技能与 UHR 个体随访时满足 MDD 标准独立相关,而更好的语言流畅性和处理速度的新发现与 MDD 结果相关。因此,神经认知表现应被视为 MDD 结果风险的标志和 UHR 中 MDD 管理的目标。较差的语言记忆和较高的语言流畅性与 12 个月时的 MDD 显着相关(分别为 p = .04 和 0.026)。此外,在中期随访中,较高的处理速度与 MDD 显着相关(p = .047)。这些发现概述了神经认知技能与 UHR 个体随访时满足 MDD 标准独立相关,而更好的语言流畅性和处理速度的新发现与 MDD 结果相关。因此,神经认知表现应被视为 MDD 结果风险的标志和 UHR 中 MDD 管理的目标。这些发现概述了神经认知技能与 UHR 个体随访时满足 MDD 标准独立相关,而更好的语言流畅性和处理速度的新发现与 MDD 结果相关。因此,神经认知表现应被视为 MDD 结果风险的标志和 UHR 中 MDD 管理的目标。这些发现概述了神经认知技能与 UHR 个体随访时满足 MDD 标准独立相关,而更好的语言流畅性和处理速度的新发现与 MDD 结果相关。因此,神经认知表现应被视为 MDD 结果风险的标志和 UHR 中 MDD 管理的目标。
更新日期:2020-04-01
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