Functional cerebral asymmetries (FCAs) are a fundamental principle of brain organisation. While specific patterns of asymmetry are characteristic of healthy human brains, atypical or reduced FCAs have been reported for several psychotic disorders, including schizophrenia and mood disorders. However, it is unclear whether atypical FCAs reflect a predisposition to psychotic disorders or a compensatory neural strategy for the progressive structural and functional changes in the brain associated with psychosis. A separate stream of research has demonstrated the antipsychotic effects of sex hormones in clinical populations. Moreover, modern neuroscience has shown that sex hormones, particularly estrogen and progesterone, can affect FCAs due to their organising effects (e.g., during prenatal development), and also by their activating effects throughout life (e.g., in younger women during the menstrual cycle or in post-menopausal women as a consequence of hormone therapy). By combining these research streams, this narrative literature review explores the relationship between the neuromodulatory properties of estrogen, FCAs and psychotic and psychotic-like symptoms. This research is not only of theoretical interest for the understanding of FCAs and psychotic symptoms, but might also be of clinical relevance for the development of stratified treatment approaches for women and men suffering from psychosis and mood disorders.

中文翻译：

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性激素和非典型半球不对称的抗精神病作用。

功能性脑不对称（FCA）是大脑组织的基本原理。尽管特定的不对称模式是健康的人脑的特征，但已报道了一些精神病性疾病（包括精神分裂症和情绪障碍）的非典型或减少的FCA。然而，目前尚不清楚非典型FCA是否反映了精神病的易感性或针对与精神病相关的大脑中进行性结构和功能变化的补偿性神经策略。另有研究表明，性激素在临床人群中具有抗精神病作用。此外，现代神经科学表明，性激素，尤其是雌激素和孕激素，由于其组织作用（例如，在产前发育过程中）会影响FCA，以及它们在一生中的激活作用（例如，由于激素疗法，在月经周期中的年轻女性或绝经后的女性中）。通过结合这些研究流，这篇叙述性文献综述探索了雌激素，FCA的神经调节特性与精神病和精神病状症状之间的关系。这项研究不仅对于理解FCA和精神病性症状具有理论意义，而且对于开发针对患有精神病和情绪障碍的男女分层治疗方法的临床意义也可能具有临床意义。这篇叙述性文献综述探讨了雌激素，FCA的神经调节特性与精神病和精神病样症状之间的关系。这项研究不仅对于理解FCA和精神病性症状具有理论意义，而且对于开发针对患有精神病和情绪障碍的男女的分层治疗方法也可能具有临床意义。这篇叙述性文献综述探讨了雌激素，FCA的神经调节特性与精神病和精神病样症状之间的关系。这项研究不仅对于理解FCA和精神病性症状具有理论意义，而且对于开发针对患有精神病和情绪障碍的男女分层治疗方法的临床意义也可能具有临床意义。