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Biomonitoring data on young adults from the Environmental Specimen Bank suggest a decrease in the exposure to the fragrance chemical 7-hydroxycitronellal in Germany from 2000 to 2018.
International Journal of Hygiene and Environmental Health ( IF 4.5 ) Pub Date : 2020-03-12 , DOI: 10.1016/j.ijheh.2020.113508
Nikola Pluym 1 , Wolf Petreanu 1 , Till Weber 2 , Gerhard Scherer 1 , Max Scherer 1 , Marike Kolossa-Gehring 2
Affiliation  

7-Hydroxy-3,7-dimethyl-1-octanal, also known as 7-hydroxycitronellal (7-HC, CAS No. 107-75-5) is a synthetic fragrance widely used in cosmetic and hygiene products. Because of its wide spread use and its known sensitizing properties, 7-HC was selected as one of 50 chemicals within the frame of the cooperation project between the German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) and the German Chemical Industry Association (VCI) to develop a suitable human biomonitoring (HBM) method in order to assess the exposure of the general population in Germany. Within this scope, the recently published analytical method for urinary 7-hydroxycitronellylic acid (7-HCA), the major metabolite of 7-HC, was applied to 329 24h-urine samples of young adults (20 to 29 years) collected between 2000 and 2018 and stored in the Environmental Specimen Bank (ESB). The widespread exposure to 7-HC as already observed in a pilot study with 40 volunteers could be confirmed with quantifiable concentrations of 7-HCA in all 329 study samples (mean: 14.9 ng/mL; median: 8.1 ng/mL). A significant, chronological decrease in 7-HCA levels was found for the monitored years (2000, 2004, 2008, 2012, 2015, 2018). The most pronounced decline occurred between 2000 and 2004 (means: 34.37 versus 23.31, medians: 20.97 versus 12.49 μg/24h; p < 0.01). On average, females exhibited higher levels of urinary 7-HCA compared to males (29.34 versus 17.21 μg/24h, p < 0.05). Based on the urinary 7-HCA excretion, the daily intake (DI) of 7-HC normalized for body weight (bw) was estimated. Over all sampling years, average DI in females was significantly higher compared to males (0.99 versus 0.46 μg/kg bw/d). Assuming dermal exposure as the main route of 7-HC intake, the mean DIs correspond to <0.1% of the derived no effect level (DNEL) of 1,100 μg/kg bw/d defined by the European Chemical Agency (ECHA). The presented results for the exposure to the widely used fragrance 7-HC in Germany can be substantiated by applying the described methodology to the representative cohort of the launched German Environmental Survey in adults (GerES VI).



中文翻译:

来自环境标本库的有关年轻人的生物监测数据表明,从2000年到2018年,德国对香精化学品7-羟基香茅醛的接触量有所减少。

7-羟基-3,7-二甲基-1-辛醛(也称为7-羟基香茅醛)(7-HC,CAS编号107-75-5)是一种广泛用于化妆品和卫生产品的合成香料。由于其广泛的用途和已知的敏化特性,在德国联邦环境,自然保护与核安全部(BMU)与德国化学部之间的合作项目框架内,选择了7-HC作为50种化学品之一工业协会(VCI)开发了一种合适的人体生物监测(HBM)方法,以评估德国普通民众的接触情况。在此范围内,最近发表的尿中7-HC的主要代谢物尿7-羟基香柠檬酸(7-HCA)的分析方法 该方法应用于2000年至2018年期间收集的329个20至29岁年轻人的24小时尿液样本,并存储在环境标本库(ESB)中。在所有329个研究样品中,可量化的7-HCA浓度(平均值:14.9 ng / mL;中位数:8.1 ng / mL)可以证实,已经在40名志愿者的试点研究中观察到了广泛的7-HC暴露。在所监测的年份(2000、2004、2008、2012、2015、2018),发现7-HCA水平按时间顺序显着下降。最明显的下降发生在2000年至2004年之间(平均值:34.37 在所监测的年份(2000年,2004年,2008年,2012年,2015年,2018年)发现7-HCA含量呈时间顺序下降。最明显的下降发生在2000年至2004年之间(平均值:34.37 在所监测的年份(2000年,2004年,2008年,2012年,2015年,2018年)发现7-HCA含量呈时间顺序下降。最明显的下降发生在2000年至2004年之间(平均值:34.37相对于23.31,中位数:20.97相对于12.49μg/ 24h;p <0.01)。平均而言,女性比男性表现出较高的尿7-HCA水平(29.3417.21μg/ 24h,p <0.05)。根据尿液中的7-HCA排泄量,估算了按体重(bw)标准化的7-HC的每日摄入量(DI)。在所有采样年中,雌性的平均DI明显高于雄性(0.99比0.46μg/ kg bw / d)。假设皮肤暴露是摄入7-HC的主要途径,则平均DI值相当于欧洲化学局(ECHA)定义的1,100μg/ kg bw / d的衍生无效水平(DNEL)的<0.1%。通过将描述的方法应用于已开展的德国成人环境调查(GerES VI)的代表队列中,可以证实在德国广泛使用的香料7-HC的暴露结果。

更新日期:2020-03-12
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