In this study, the effect of using different types of fuel and various amounts of Si⁴⁺ ions on the biological properties of silicon-doped calcium phosphates (CaPs), which were synthesized using solution combustion method were investigated. X-ray diffraction (XRD) patterns showed that hydroxyapatite/beta-tricalcium phosphate (HA/βTCP) was crystallized in all synthesized samples. The synthesized sample using glycine as fuel, which doped with 0.1 mol Si⁴⁺ ions exhibited the most desirable properties. Consecutively, the zeta potential and specific surface area were enhanced from −20 to −27 mV and 38 to 146 m²/g, respectively, by increasing the amount of Si⁴⁺ ions from 0 to 0.1 mol. The bioactivity of the samples immersed in simulated body fluid (SBF) was innovatively determined by the joint analyses of the tensiometer, inductively coupled plasma (ICP), field emission scanning electron microscopy (FESEM), and XRD data. These findings plus theoretical calculations demonstrate, for the first time, that the Si⁴⁺ doping could improve the bioactivity of the powders up to ~155%. The results of in vitro cell-based experiments, including cell viability, alizarin red staining, and cell attachment, confirmed the positive effects of Si-doped powders in the biological systems. Furthermore, Si-doped powders were able to improve the migration ability of mammalian cells in vitro; they could be considered good candidates in angiogenesis-based therapeutic strategies.

在这项研究中，研究了使用不同类型的燃料和各种量的Si ⁴⁺离子对通过溶液燃烧法合成的硅掺杂磷酸钙（CaPs）生物学特性的影响。X射线衍射（XRD）图谱显示，在所有合成样品中，羟基磷灰石/β-磷酸三钙（HA /βTCP）均已结晶。使用甘氨酸作为燃料的合成样品，掺有0.1 mol Si ⁴⁺离子，表现出最理想的性能。连续地，通过增加Si ⁴⁺的含量，ζ电位和比表面积分别从-20增强到-27 mV和38增强到146 m ² / g。离子从0到0.1摩尔。通过张力计，电感耦合等离子体（ICP），场发射扫描电子显微镜（FESEM）和XRD数据的联合分析，创新地确定了浸入模拟体液（SBF）中的样品的生物活性。这些发现和理论计算首次证明，Si ⁴⁺掺杂可以将粉末的生物活性提高至〜155％。结果在体外基于细胞的实验，包括细胞活力，茜素红染色，以及细胞附着，证实Si掺杂粉末在生物系统中的积极作用。此外，掺硅粉末能够提高哺乳动物细胞的体外迁移能力。; 在基于血管生成的治疗策略中，它们可以被认为是很好的候选者。