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Hierarchical Representations of Aggression in a Hypothalamic-Midbrain Circuit.
Neuron ( IF 14.7 ) Pub Date : 2020-03-11 , DOI: 10.1016/j.neuron.2020.02.014 Annegret L Falkner 1 , Dongyu Wei 2 , Anjeli Song 3 , Li W Watsek 2 , Irene Chen 2 , Patricia Chen 4 , James E Feng 2 , Dayu Lin 5
Neuron ( IF 14.7 ) Pub Date : 2020-03-11 , DOI: 10.1016/j.neuron.2020.02.014 Annegret L Falkner 1 , Dongyu Wei 2 , Anjeli Song 3 , Li W Watsek 2 , Irene Chen 2 , Patricia Chen 4 , James E Feng 2 , Dayu Lin 5
Affiliation
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Although the ventromedial hypothalamus ventrolateral area (VMHvl) is now well established as a critical locus for the generation of conspecific aggression, its role is complex, with neurons responding during multiple phases of social interactions with both males and females. It has been previously unclear how the brain uses this complex multidimensional signal and coordinates a discrete action: the attack. Here, we find a hypothalamic-midbrain circuit that represents hierarchically organized social signals during aggression. Optogenetic-assisted circuit mapping reveals a preferential projection from VMHvlvGlut2 to lPAGvGlut2 cells, and inactivation of downstream lPAGvGlut2 populations results in aggression-specific deficits. lPAG neurons are selective for attack action and exhibit short-latency, time-locked spiking relative to the activity of jaw muscles during biting. Last, we find that this projection conveys male-biased signals from the VMHvl to downstream lPAGvGlut2 neurons that are sensitive to features of ongoing activity, suggesting that action selectivity is generated by a combination of pre- and postsynaptic mechanisms.
中文翻译：
下丘脑-微脑回路中的侵略性的层次表示。
尽管腹侧下丘脑腹外侧区（VMHvl）现在已被确定为产生同种侵略的关键场所，但其作用非常复杂，神经元在与男性和女性的社交互动的多个阶段均做出反应。以前尚不清楚大脑如何利用这种复杂的多维信号并协调离散动作：攻击。在这里，我们发现了下丘脑-中脑回路，该回路代表了侵略过程中按等级组织的社会信号。光遗传学辅助电路图揭示了从VMHvlvGlut2到lPAGvGlut2细胞的优先投射，下游lPAGvGlut2群体的失活导致了特定于攻击的缺陷。lPAG神经元对攻击行为具有选择性，并表现出短潜伏期，咬合期间相对于下颌肌肉活动的时间锁定尖峰。最后，我们发现此投影将VMHv1的男性偏向信号传递到对正在进行的活动特征敏感的下游lPAGvGlut2神经元，这表明通过突触前和突触后机制的组合产生了动作选择性。
更新日期：2020-03-11
中文翻译：
下丘脑-微脑回路中的侵略性的层次表示。
尽管腹侧下丘脑腹外侧区（VMHvl）现在已被确定为产生同种侵略的关键场所，但其作用非常复杂，神经元在与男性和女性的社交互动的多个阶段均做出反应。以前尚不清楚大脑如何利用这种复杂的多维信号并协调离散动作：攻击。在这里，我们发现了下丘脑-中脑回路，该回路代表了侵略过程中按等级组织的社会信号。光遗传学辅助电路图揭示了从VMHvlvGlut2到lPAGvGlut2细胞的优先投射，下游lPAGvGlut2群体的失活导致了特定于攻击的缺陷。lPAG神经元对攻击行为具有选择性，并表现出短潜伏期，咬合期间相对于下颌肌肉活动的时间锁定尖峰。最后，我们发现此投影将VMHv1的男性偏向信号传递到对正在进行的活动特征敏感的下游lPAGvGlut2神经元，这表明通过突触前和突触后机制的组合产生了动作选择性。
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