A variety of isoxazolo[2,3-c]quinazolines were synthesized via a [3+2] cycloaddition of quinazoline-3-oxides with acrylates. The reaction exhibits a broad substrate scope and good functional group tolerance. The corresponding isoxazolo[2,3-c]quinazolines can be obtained in good to excellent yields in 1,4-dioxane.

中文翻译：

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异环唑啉[2,3- c ]喹唑啉的合成是通过环加成喹唑啉-3-氧化物和丙烯酸酯

通过将喹唑啉-3-氧化物与丙烯酸酯进行[3 + 2]环加成反应，合成了多种异恶唑啉[2,3-c]喹唑啉。该反应表现出较宽的底物范围和良好的官能团耐受性。相应的异恶唑并[2，3-c]喹唑啉可以在1，4-二恶烷中以良好的产率获得。